ArticlePituitary2025
Cognitive function and fatigue before and after transsphenoidal surgery in patients with pituitary adenoma: a prospective study.
Article in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Fatigue trajectory and its associated factors in patients after pituitary adenoma surgery: a longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Postoperative screening for distress symptom cluster in patients with pituitary adenomas: a propensity-score matched outcome analysis.Frontiers in neurologyArticle
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10 authors.
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Abstract
purposeThe aim of this prospective longitudinal study was to evaluate cognitive function and fatigue before and 12 months after transsphenoidal surgery (TSS) for a pituitary adenoma.
methodsThis study was part of the Gothenburg Pituitary Tumour Study, which consecutively includes patients undergoing TSS at Sahlgrenska University Hospital. Adult patients with a pituitary adenoma were recruited between October 2016 and May 2021. Cognitive function and fatigue were evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Multidimensional Fatigue Inventory (MFI-20). Paired comparisons were made for total and subscale scores before and after TSS. Based on normative data, individual scores were classified into one of three categories for symptom severity (normal, moderate, or severe) before and after TSS.
resultsFifty-nine patients (31 females) were included. Among them, 42 had non-functioning pituitary adenomas (NFPA) and 17 had a functioning pituitary adenoma. There were no differences in RBANS total or domain indices before and 12 months after surgery except for the attention index which improved. Total MFI-20 and all subscale scores improved. The improvement was more pronounced in patients with functioning pituitary adenoma, who reported worse fatigue before surgery compared to patients with NFPA. Individual differences between pre- and postoperative scores that also changed category of symptom severity were seen for 37% of all patients regarding cognition and for 35% regarding fatigue. Improvements accounted for the majority of these changes.
conclusionCognitive function remained largely unchanged from before to 12 months after TSS, while self-reported fatigue improved.
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