ArticleJournal of exposure science & environmental epidemiology2026
Air pollution and preterm birth: comparing trimester average and repeated threshold exposure metrics in a North Carolina birth cohort, 2003-2015.
Article in Journal of exposure science & environmental epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundExposures to ambient air pollutants during pregnancy are associated with preterm birth (PTB) in studies that evaluate average pollutant concentrations during potential "windows of susceptibility," referred to as critical windows.
objectiveWe evaluated associations between ozone (O
methodsWe analyzed data from North Carolina (NC) birth certificates from the NC Birth Defects Monitoring Program, limited to live, singleton births without birth defects and delivered from 2003-2015. The EPA's Fused Air Quality Surface Using Downscaling (fCMAQ) model was used to assign exposures for trimester-average and daily threshold exceedances for O
resultsAmong the cohort of 1,368,370 births, 8.4% were PTBs. The number of daily exposure exceedances ranged from 0 to 81 days over different threshold concentrations during trimester 1 or 2. There was slight to moderate agreement in risk associated with trimester average and daily threshold exposures exceedances, with decreased agreement among higher threshold concentrations. RDs ranged from -31 to 29 for average O SIGNIFICANCE: This study provides insights into the heterogeneity in risk of PTB when assessing different air pollution exposure metrics. IMPACT: This study investigates the impact of O
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