Evidence map›Paper›PMID 40329010›Full record

ReviewDiscover oncology2025

Progress of the application of spatially fractionated radiation therapy in palliative treatment of tumors.

Hongfu Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Hongfu ZhaoDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, 130033, Jilin, China. zhaohf@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION/

backgroundMalignant tumors pose a serious threat to human health. As tumor volume increases, conventional external beam radiation therapy (cEBRT) faces challenges in tumor control and normal tissue toxicity. Spatially fractionated radiation therapy (SFRT) has emerged as an alternative approach. MATERIALS AND

methodsThis article reviews the history of SFRT, including kilovolt X-ray based GRID, megavolt X-ray based GRID, MLC-shaped GRID, LATTICE radiation therapy (LRT), Bragg-peak based SFRT, microbeam, minibeam, SBRT-PATHY, and ISPART. It also explores its radiobiological mechanisms, such as immunomodulation, bystander and abscopal effects, and vascular response. Clinical studies of SFRT in palliative tumor treatment are summarized, and its limitations and future directions are discussed.

resultsSFRT has shown high symptom remission rates, significant target volume reduction, and even tumor control and long-term survival in some cases across various tumor types. However, it has limitations like lack of standardized dosimetric parameters, complex implementation, small-scale clinical studies, and uncertain immunomodulatory potential.

conclusionDespite limitations, SFRT shows promise as a palliative radiation therapy technique. Future large-scale, multi-center clinical trials are needed to standardize dosimetric parameters, clarify immunomodulatory mechanisms, and simplify the technology for wider application.

Indexed as

Palliative treatmentProgressSpatially fractionated radiation therapy

Identifiers

PMID40329010
PMCPMC12055688

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.