Evidence map›Paper›PMID 40328971›Full record

ArticleGene therapy2025

Nitrous oxide enhances MR-guided focused ultrasound delivery of gene therapy to the murine hippocampus.

Deepshikha Bhardwaj, Ibrahim Youssef, Darren Imphean, Sydni K Holmes, Venugopal Krishnan, Sandi Jo Estill-Terpack, Marc Diamond, Rajiv Chopra, Rachel M Bailey, Bhavya R Shah

Abstract read
In one paragraph

Article in Gene therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deepshikha Bhardwaj *Transcranial Focused Ultrasound Lab, UTSW Medical Center, Dallas, TX, USA.
Ibrahim Youssef *Transcranial Focused Ultrasound Lab, UTSW Medical Center, Dallas, TX, USA.ORCID 0000-0003-2228-0368
Darren ImpheanTranscranial Focused Ultrasound Lab, UTSW Medical Center, Dallas, TX, USA.
Sydni K HolmesCenter for Alzheimer's and Neurodegenerative Diseases, UTSW Medical Center, Dallas, TX, USA.
Venugopal KrishnanTranscranial Focused Ultrasound Lab, UTSW Medical Center, Dallas, TX, USA.ORCID 0000-0002-4100-0002
Sandi Jo Estill-TerpackCenter for Alzheimer's and Neurodegenerative Diseases, UTSW Medical Center, Dallas, TX, USA.
Marc DiamondCenter for Alzheimer's and Neurodegenerative Diseases, UTSW Medical Center, Dallas, TX, USA.
Rajiv ChopraTranscranial Focused Ultrasound Lab, UTSW Medical Center, Dallas, TX, USA.
Rachel M BaileyCenter for Alzheimer's and Neurodegenerative Diseases, UTSW Medical Center, Dallas, TX, USA.ORCID 0000-0002-5909-5548
Bhavya R Shah *Transcranial Focused Ultrasound Lab, UTSW Medical Center, Dallas, TX, USA. Bhavya.Shah@utsouthwestern.edu.ORCID 0000-0002-0058-6174

Funding

Gene Therapy Delivery for Age-related Neurodegenerative DiseasesR01AG078417 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI Rachel M Bailey · 2023 to 2026
$2.9M
NIA NIH HHS R01 AG078417U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R01NS127900-01A1
6 · The paper itself

Abstract

Transcranial Magnetic Resonance Guided Focused Ultrasound can oscillate intravenously delivered microbubbles and transiently open the blood brain barrier (BBB) in a targeted brain region. However, high microbubble doses or Focused ultrasound pressures (FUS) leads to injury. So, we administered nitrous oxide (N

Indexed as

Genetic TherapyGene Transfer TechniquesHippocampusNitrous OxideAnimalsBlood-Brain BarrierGenetic VectorsMagnetic Resonance ImagingMiceMicrobubblesNitrous Oxide

Identifiers

PMID40328971
PMCPMC12823095

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.