ArticleScientific reports2025
An open source statistical web application for validation and analysis of virtual cohorts.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
The conventional approach to developing medical treatments and medical devices usually covers pre-clinical and in-vitro investigations, in-vivo animal studies and clinical trials with humans. In-silico trials and virtual cohorts present a promising avenue for addressing the challenges inherent in clinical research and improving its efficiency. Despite considerable advancements in the field of in-silico trials, several notable gaps and challenges still need to be addressed, one is the limited availability of open and user-friendly statistical tools to support the specific analysis of virtual cohorts and in-silico trials. In the EU-Horizon funded project SIMCor we have developed a web application, providing a R-statistical environment supporting the validation of virtual cohorts and the application of validated cohorts for in-silico trials. It provides a practical platform for validating cohorts and has implemented existing statistical techniques that can be applied to compare virtual cohorts with real datasets. It is fully open, generic and menu driven and provides user guidance and help ( https://github.com/ecrin-github/SIMCor , https://zenodo.org/records/14718597 ).The tool has been developed according to specified user requirements and has been extensively tested and validated. Important next steps are to gain more experience with the tool in other domains and research environments and to extend its functionality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.