Evidence map›Paper›PMID 40328820›Full record

ArticleNature communications2025

Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease.

Kyle L O'Donnell, Hanna Anhalt, Greg Saturday, Nikole L Warner, Troy Hinkley, E Taylor Stone, Kiara Hatzakis, Amit P Khandhar, Logan Banadyga, Jesse H Erasmus and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Five Hot Topics in Tropical Medicine: 2025.Infectious disease reports · 2026
    Review
  2. A Single-Dose Bundibugyo Virus Vaccine Protects Macaques Within 3 Days.bioRxiv : the preprint server for biology · 2026
    Article
  3. CD4Nature immunology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kyle L O'DonnellLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.ORCID http://orcid.org/0000-0002-7183-1966
Hanna AnhaltLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.ORCID http://orcid.org/0000-0002-0799-3039
Greg SaturdayRocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.ORCID http://orcid.org/0000-0002-0803-6177
Nikole L WarnerHDT Bio, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2307-5529
Troy HinkleyHDT Bio, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4833-0255
E Taylor StoneHDT Bio, Seattle, WA, USA.
Kiara HatzakisHDT Bio, Seattle, WA, USA.
Amit P KhandharHDT Bio, Seattle, WA, USA.
Logan BanadygaSpecial Pathogens Program National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.ORCID http://orcid.org/0000-0001-8390-2648
Jesse H ErasmusHDT Bio, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1612-2697
Andrea MarziLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. marzia@niaid.nih.gov.ORCID http://orcid.org/0000-0003-0186-9587

Funding

Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI001254
6 · The paper itself

Abstract

The Sudan virus (SUDV) outbreaks in Uganda in 2022 and 2025 created public health concerns in-country and the entire East African region. There are currently no licensed countermeasures against SUDV. We developed a SUDV vaccine candidate based on a nanocarrier (LION

Indexed as

Ebola VaccinesEbolavirusHemorrhagic Fever, EbolaRepliconViral VaccinesAnimalsAntibodies, ViralDisease Models, AnimalFemaleGuinea PigsVaccinationVirus ReplicationAntibodies, ViralEbola VaccinesViral Vaccines

Identifiers

PMID40328820
PMCPMC12056027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.