ArticleScientific reports2025
The effect of visfatin on the transcriptomic profile of porcine anterior pituitary cells during periimplantation period.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Females' reproductive capacity is closely related to the actual metabolic status of the organism. The pituitary, an element of the regulatory hypothalamic-pituitary-ovarian axis, is one of the most important endocrine glands regulating reproductive system activity. Undisturbed functioning of pituitary ensures the regular course of pregnancy through, among others, the modulation of steroid hormones production, which is critical in the early stages of gestation. Visfatin, a hormone belonging to the adipokines family, may belong to a group of factors regulating the reproductive functions in response to the female's metabolic status. Herein we verified the hypothesis assuming a modulatory effect of visfatin on the porcine anterior pituitary transcriptome on days 15 to 16 of gestation (beginning of implantation). RNA-seq analysis of the porcine anterior pituitary cells revealed changes in the expression of 203 genes (121 up-regulated and 82 down-regulated, when compared to the non-treated controls), assigned to 325 gene ontology terms. The presence of visfatin affected the frequency of alternative splicing events (194 cases), as well as long noncoding RNA expression (64 cases). Visfatin expression and the occurrence of alternative splicing events of genes that are responsible, directly or indirectly, for regulation of the secretory functions of the pituitary, including those critical for reproductive functions suggests that the adipokine may be a key agent in ensuring the appropriate hormonal milieu during the peri-implantation period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.