Evidence map›Paper›PMID 40328616›Full record

ArticleActa biomaterialia2025

Large animal model of controlled peripheral artery calcification.

Alexey Kamenskiy, Barbara Batista de Oliveira, Frazer Heinis, Pranav Renavikar, John Eberth, Jason MacTaggart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexey KamenskiyDepartment of Biomechanics, University of Nebraska Omaha, Omaha, NE, USA. Electronic address: akamenskiy@unomaha.edu.
Barbara Batista de OliveiraDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.
Frazer HeinisDepartment of Biomechanics, University of Nebraska Omaha, Omaha, NE, USA.
Pranav RenavikarDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
John EberthSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
Jason MacTaggartDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: jmactaggart@unmc.edu.

Funding

Tissue Analysis Core (TAC)P20GM152301 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI Alexey Kamenskiy · 2024 to 2026
$8.8M
Optimized Stents for the Femoropopliteal ArteryR01HL125736 · NHLBI · UNIVERSITY OF NEBRASKA OMAHA · PI KAMENSKIY, ALEXEY, MACTAGGART, JASON · 2015 to 2024
$6.3M
Effects of aortic compliance and Windkessel reduction on cardiac and aortic pathophysiologyR01HL147128 · NHLBI · UNIVERSITY OF NEBRASKA OMAHA · PI DESYATOVA, ANASTASIA S · 2019 to 2023
$3.0M
NHLBI NIH HHS R01 HL125736NHLBI NIH HHS R01 HL147128NIGMS NIH HHS P20 GM152301
6 · The paper itself

Abstract

Peripheral artery disease (PAD) in the lower extremity arteries leads to significant morbidity and mortality. Arterial calcification contributes to poor clinical outcomes and greatly increases the risk of amputation. Current treatments for calcific lesions are limited and yield suboptimal results. A large animal model that closely mimics calcific PAD and accommodates human-sized devices could enhance the development of safer and more effective therapies. Our objective was to create a swine model of late-stage arterial calcification to test the efficacy and side effects of surgical interventions. To induce lesions, swine received injections of CaCl

Indexed as

Disease Models, AnimalPeripheral Arterial DiseaseVascular CalcificationAnimalsHumansSwineArterial calcificationCalcium chloride inductionLarge animal modelPeripheral artery diseaseSwine

Identifiers

PMID40328616
PMCPMC12513339

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.