Evidence map›Paper›PMID 40328513›Full record

ArticleDrug and alcohol review2025

Applying a Modified Version of the Prediction of Alcohol Withdrawal Severity Scale in a Canadian Community Withdrawal Management Setting.

Hannah Crepeault, Nicole Cowan, M Eugenia Socias, Niloofar Riazi, Alison Knill, Avneet Khela, Evan Wood, Lianping Ti

Abstract read
In one paragraph

Article in Drug and alcohol review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah CrepeaultBritish Columbia Centre on Substance Use, Vancouver, Canada.
Nicole CowanVancouver Detox Centre, Vancouver Coastal Health, Vancouver, Canada.
M Eugenia SociasBritish Columbia Centre on Substance Use, Vancouver, Canada.ORCID 0000-0003-2556-7049
Niloofar RiaziVancouver Detox Centre, Vancouver Coastal Health, Vancouver, Canada.
Alison KnillBritish Columbia Centre on Substance Use, Vancouver, Canada.
Avneet KhelaVancouver Detox Centre, Vancouver Coastal Health, Vancouver, Canada.
Evan WoodBritish Columbia Centre on Substance Use, Vancouver, Canada.
Lianping TiBritish Columbia Centre on Substance Use, Vancouver, Canada.ORCID 0000-0003-2470-438X

Funding

Evaluation of Drug Checking as a Novel Intervention to Address the Opioid Overdose Crisis Attributable to Fentanyl and its AnaloguesR01DA052381 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI TI, LIANPING · 2021 to 2023
$1.4M
Ministry of Health, British ColumbiaNIDA NIH HHS R01 DA052381US National Institutes of Health R01DA052381Vancouver Coastal Health Research Institute F19-02790
6 · The paper itself

Abstract

introductionSevere alcohol withdrawal syndrome (SAWS) can lead to significant morbidity and mortality. The Prediction of Alcohol Withdrawal Severity Scale (PAWSS) has been validated in general acute care environments, but its efficacy in withdrawal management settings remains underexplored. This study aimed to assess the utility of a modified PAWSS and identify appropriate cutoff scores in a community withdrawal management setting in Vancouver, Canada.

methodsFrom October 2019 to September 2022, we reviewed charts at Vancouver Detox Centre. Modified PAWSS versions replaced question 9 on the original PAWSS with: (i) breath analysis readings; (ii) alcohol consumption in the previous 24 h; and (iii) clinical assessments. We performed receiver operating characteristic analysis and used Youden's index to determine modified PAWSS' diagnostic accuracy against SAWS presentation, defined by a score of 15 or greater on the Clinical Institute Withdrawal Assessment Alcohol, Revised, seizures or delirium tremens and/or benzodiazepine administration.

resultsAmong 228 individuals (165 male, 63 female), 175 (75%) met SAWS criteria during admission. For breath analysis readings, an optimal PAWSS cutoff score had 55% sensitivity (95% confidence interval [CI] 46%-63%) and 74% specificity (95% CI 54%-87%). For alcohol consumption in the last 24 h, a cutoff score of 7 had 44% sensitivity (95% CI 36%-51%) and 85% specificity (95% CI 70%-93%). For clinical assessment, a cutoff score of 6 had 53% sensitivity (95% CI 45%-61%) and 71% specificity (95% CI 58%-85%). DISCUSSION AND

conclusionsWithin a community withdrawal setting, the prevalence of SAWS was high, rendering the modified PAWSS less valuable. Although higher cutoff scores improved specificity, poor sensitivity hindered identification of low-risk SAWS individuals.

Indexed as

AlcoholismSeverity of Illness IndexSubstance Withdrawal SyndromeAdultBreath TestsCanadaFemaleHumansMaleMiddle AgedRetrospective Studiesalcoholcommunity withdrawal managementprediction of alcohol withdrawal severity scalesevere alcohol withdrawal syndrome

Identifiers

PMID40328513
PMCPMC12228024

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.