Evidence map›Paper›PMID 40328315›Full record

ArticleNature2025

Naturally ornate RNA-only complexes revealed by cryo-EM.

Rachael C Kretsch, Yuan Wu, Svetlana A Shabalina, Hyunbin Lee, Grace Nye, Eugene V Koonin, Alex Gao, Wah Chiu, Rhiju Das

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
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  14. Article
  15. TheNon-coding RNA · 2025
    Article
  16. De novo design of RNA and nucleoprotein complexes.bioRxiv : the preprint server for biology · 2025
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachael C KretschBiophysics Program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6935-518X
Yuan WuHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Svetlana A ShabalinaComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3774-819X
Hyunbin LeeDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0006-1911-435X
Grace NyeDivision of CryoEM and Bioimaging, SSRL-SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Eugene V KooninComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3943-8299
Alex GaoBiophysics Program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3579-0327
Wah ChiuBiophysics Program, Stanford University, Stanford, CA, USA. wahc@stanford.edu.ORCID 0000-0002-8910-3078
Rhiju DasBiophysics Program, Stanford University, Stanford, CA, USA. rhiju@stanford.edu.ORCID 0000-0001-7497-0972

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Next-generation computational/chemical methods for complex RNA structuresR35GM122579 · NIGMS · STANFORD UNIVERSITY · PI Rhiju Das · 2017 to 2026
$7.2M
NIGMS NIH HHS R35 GM122579NIGMS NIH HHS U24 GM129541
6 · The paper itself

Abstract

The structures of natural RNAs remain poorly characterized and may hold numerous surprises

Indexed as

Cryoelectron MicroscopyRNA, BacterialModels, MolecularNucleic Acid ConformationRNA, Bacterial

Identifiers

PMID40328315
PMCPMC12286853

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.