Evidence map›Paper›PMID 40328237›Full record

ArticleThe American journal of tropical medicine and hygiene2025

Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid.

Jill Teitelbaum, Shivank Madan, Snehal Patel, Christina Coyle, Charles Y Chiu, Phyu M Thwe, Mayuko Uehara, Rita Jermyn, Vagish Hemmige

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PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jill TeitelbaumAlbert Einstein College of Medicine, Bronx, New York.
Shivank MadanAlbert Einstein College of Medicine, Bronx, New York.
Snehal PatelAlbert Einstein College of Medicine, Bronx, New York.
Christina CoyleAlbert Einstein College of Medicine, Bronx, New York.
Charles Y ChiuDepartment of Laboratory Medicine and UCSF Clinical Microbiology Laboratory, University of California San Francisco, San Francisco, California.
Phyu M ThweAlbert Einstein College of Medicine, Bronx, New York.
Mayuko UeharaMontefiore Medical Center, Bronx, New York.
Rita JermynMontefiore Medical Center, Bronx, New York.
Vagish HemmigeAlbert Einstein College of Medicine, Bronx, New York.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas meningoencephalitis can present in immunocompromised patients after organ transplantation. We present the first reported instance in which metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid diagnosed Chagas meningoencephalitis in a patient. The diagnosis of Chagas in this case underscores the role of mNGS in identifying rare or unexpected pathogens.

Indexed as

Chagas DiseaseHeart TransplantationMeningoencephalitisTrypanosoma cruziHigh-Throughput Nucleotide SequencingHumansImmunocompromised HostMaleMetagenomicsMiddle Aged

Identifiers

PMID40328237
PMCPMC12225569

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.