ArticleTuberculosis (Edinburgh, Scotland)2025
IL-27 signaling limits the diversity of antigen-specific T cells and interferes with protection induced by BCG vaccination.
Ashley M Divens, Kenneth J Ryan, Alessandro Sette, Cecilia S Lindestam Arlehamn, Cory M Robinson
Abstract read
In one paragraphArticle in Tuberculosis (Edinburgh, Scotland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
Ashley M DivensDepartment of Microbiology, Immunology, & Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.
Kenneth J RyanDepartment of Statistics, West Virginia University, Morgantown, WV, USA.
Alessandro SetteCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Cecilia S Lindestam ArlehamnCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA; Center for Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Cory M RobinsonDepartment of Microbiology, Immunology, & Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, USA. Electronic address: cory.robinson1@hsc.wvu.edu.
Funding
West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Anne Courtney DeVries · 2012 to 2026
$81.0MWV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Travis Salisbury · 2012 to 2026
$61.1MWVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Dominique Bollino · 2018 to 2026
$22.4MElucidating the mechanisms and consequences of MDSC-regulated immunity in TBR01AI164970 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bryan David Bryson, Joshua T. Mattila · 2022 to 2026
$2.7MUnderstanding IL-27 as a negative regulator of protective immunity during neonatal sepsisR01AI163333 · NIAID · WEST VIRGINIA UNIVERSITY · PI ROBINSON, CORY MICHAEL · 2021 to 2025
$2.4MSpecial Becton Dickinson Fortessa Flow CytometerS10OD016165 · OD · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2013 to 2013
$384kNIAID NIH HHS R01 AI163333NIAID NIH HHS R01 AI164970NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM121322NIGMS NIH HHS U54 GM104942NIH HHS S10 OD016165
6 · The paper itselfAbstract
Tuberculosis (TB) is the leading cause of death due to a pathogen. The live-attenuated BCG vaccine is the only approved vaccine to prevent TB, but it fails to confer long-term protection. We hypothesize that the immunosuppressive cytokine IL-27 may contribute to the inefficacies of the BCG vaccine. IL-27 is elevated in neonates, the population most commonly administered BCG, and levels increase further upon vaccination. IL-27 interferes with the phagolysosomal pathway, suggesting it may limit the diversity of antigens processed and presented to T cells. We hypothesized that in the absence of IL-27 signaling, BCG vaccination induces antigen-specific T cells that recognize a greater number of antigens and provide enhanced protection during M. tuberculosis (Mtb) challenge. CD3
Indexed as
Antigens, BacterialBCG VaccineInterleukin-27InterleukinsMycobacterium tuberculosisT-LymphocytesTuberculosisAdoptive TransferAnimalsAnimals, NewbornDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, KnockoutReceptors, InterleukinAntigens, BacterialBCG VaccineIl27 protein, mouseIl27ra protein, mouseInterleukin-27InterleukinsReceptors, InterleukinBCGInterleukin-27NeonatalTuberculosisVaccine
Identifiers
PMID40328205
PMCPMC12158641
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