ArticleNeurology2025
Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Impact of cannabis use on white matter hyperintensities in adults with and without chronic HIV disease.Journal of neurovirology · 2026Article
- Portable Low-Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus.Annals of clinical and translational neurology · 2026Article
- Impact of Delayed HIV Diagnosis and Treatment on Dementia Risk in Later Life.Open forum infectious diseases · 2026Article
- Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV.Neurology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPeople living with HIV (PWH) have increased rates of ischemic stroke even after antiretroviral therapy (ART) and viral suppression. Cerebral white matter hyperintensities (WMHs) on brain MRI are associated with an increased risk of stroke and cognitive impairment. This study sought to characterize and quantify brain WMHs during acute HIV infection and after early ART initiation compared with people without HIV.
methodsParticipants diagnosed with acute HIV infection (AHI) from the RV254/SEARCH010 cohort in Thailand and demographically matched people without HIV (PWoH) were identified. The inclusion criterion was age 18 years or older; exclusion criteria were history of psychiatric disorder, neurologic disorder, or pregnancy. Participants who had paired 3T MRI brain scans completed at enrollment and at two-year follow-up were included in the analysis. WMH data were extracted from T2 fluid-attenuated inversion recovery sequences and standardized to total intracranial volume to generate an index of WMH volume change. A repeated-measures ANOVA was used to test for WMH change over time per group, and WMH change was compared with HIV disease measures and vascular comorbidities using parametric and nonparametric testing.
resultsSeventy-two RV254 participants (PWH, 99% male) and 37 PWoH (100% male), with a mean age of 31 years, were included. PWH had a mean estimated duration of exposure to HIV of 21 days (SD = 9). Both groups had very low rates of vascular comorbidities. At baseline, the volume of WMHs did not differ between groups. However, there was a greater increase in WMH volume over 2 years in PWH (mean 21.6%) compared with PWoH (mean 5.8%, DISCUSSION: Young Thai men with AHI demonstrated greater WMH progression than PWoH over 2 years despite ART initiation and viral suppression. These data suggest that brain white matter is vulnerable to HIV during early infection, independent from vascular comorbidities or lifestyle factors. Limitations include homogeneity in sex and ethnicity and follow-up period limited to 24 months.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.