ArticleACS applied materials & interfaces2025
Tailored Mesoporous Silica Nanoparticles and the Chick Chorioallantoic Membrane: A Promising Strategy and Model for Efficient Blood-Brain Barrier Crossing.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Nanoparticles for Doxorubicin Delivery: Advances in Carrier Design and Synergistic Cancer Therapy.Topics in current chemistry (Cham) · 2026Review
- Engineering Nanocarriers for Dopamine Stabilization and Targeted Brain Delivery: Mechanisms, Approaches and Translational Challenges.International journal of nanomedicine · 2026Review
- Applications of Tailored Mesoporous Silicate Nanomaterials in Regenerative Medicine and Theranostics.International journal of molecular sciences · 2025Review
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Authors and funding
7 authors.
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Abstract
Crossing the blood-brain barrier (BBB) remains a major challenge for brain-targeted drug delivery. Mesoporous silica nanoparticles (MSNs) with tunable size and surface properties are promising vehicles for crossing the BBB. In this study, we explored the potential applications of the chick chorioallantoic membrane (CAM) model in combination with nanotherapeutics. We synthesized ∼25 nm MSNs and RITC-conjugated MSNs (RMSNs) with short PEG chains and varying amounts of positively charged molecules, specifically tertiary amine (polyethylenimine, PEI) or quaternary amine (trimethylammonium, TA), to investigate the positive charge effects on BBB penetration. Strongly positively charged TA-modified RMSNs (s-RMSN@PEG/TA, where s denotes strongly positively charged) effectively crossed the chick embryo BBB, whereas PEI-modified RMSNs did not. Although the weakly positively charged formulation (w-MSN@PEG/TA, where w denotes weakly positively charged) exhibited higher Dox loading capacity and a faster release rate, s-MSN@PEG/TA demonstrated superior BBB penetration and drug permeability. Consistent with chick CAM results, RMSN@PEG/TA also penetrated the BBB in mice. Long-chain PEG-modified RMSN@PEG/TA (RMSN@PEG
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Registered trials
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