Evidence map›Paper›PMID 40327716›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Molecular determinants of [Formula: see text] and cation transport in the human cation-dependent Cl

Marcelo A Catalán, Lisandra Flores-Aldama, Fernanda Fernández, Daniel Bustos, Natalia Apablaza, Ailen Hidalgo, Yuliet Mazola, Ella Matamala, Li Yo Kao, Ira Kurtz and 6 more

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marcelo A CatalánInstituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.ORCID 0000-0003-3544-2821
Lisandra Flores-AldamaInstituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
Fernanda FernándezInstituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
Daniel BustosLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca, Chile.ORCID 0000-0002-2136-2305
Natalia ApablazaInstituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
Ailen HidalgoInstituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
Yuliet MazolaCentro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.
Ella MatamalaInstituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
Li Yo KaoDivision of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States.
Ira KurtzDivision of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States.
Carlos SpichigerInstituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.ORCID 0000-0002-5269-8135
José M SarmientoInstituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.ORCID 0000-0001-7731-8496
Sebastián BrauchiInstituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.ORCID 0000-0002-8494-9912
Wendy GonzálezMillennium Nucleus of Ion Channel-Associated Diseases, Valdivia, Chile.ORCID 0000-0002-7535-6883
Leandro ZúñigaCentro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Casilla, Talca, Chile.
Gaspar Peña-MünzenmayerInstituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.ORCID 0000-0001-6633-0545

Funding

The Biology of NBCe1 in Health and DiseaseR01DK077162 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRA KURTZ · 2007 to 2026
$6.7M
Biogenesis of hERG1a/1b ion channels in health and disease model cardiomyocytesK99HL169909 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI FLORES ALDAMA, LISANDRA · 2023 to 2024
$339k
Allan Smith Charitable FundANID | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 11150454ANID | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1211838ANID | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1230446ANID | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1230996ANID | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1241753ANID/Universidad Austral de Chile VIDCA-ANID-INID210009Factor Family FoundationHHS | National Institutes of Health (NIH) 1K99HL169909-01Kleeman FundMillenium science initiative program, Chile NCN19_168NHLBI NIH HHS K99 HL169909NIDDK NIH HHS R01 DK077162Ralph Block Family foundationUniversidad Austral de Chile (UACh) VIDCA-INS-INV-2020-03
6 · The paper itself

Abstract

The [Formula: see text] transporter AE4 (

Indexed as

AntiportersCationsChloridesAnimalsBiological TransportHEK293 CellsHumansIon TransportMolecular Dynamics SimulationMutagenesis, Site-DirectedSodiumSodium-Bicarbonate SymportersAntiportersCationsChloridesSLC4A4 protein, humanSodiumSodium-Bicarbonate Symportersaminoacidic residuesCl−/cation- [Formula: see text] exchangerion binding sitemolecular dynamicstransport mechanism

Identifiers

PMID40327716
PMCPMC12463136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.