Evidence map›Paper›PMID 40327681›Full record

ArticlePloS one2025

The ubiquitin-like modifier FAT10 does not affect IL-12 expression and signaling.

Jinjing Cao, Gerardo Omar Alvarez Salinas, Gunter Schmidtke, Michael Basler

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In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jinjing CaoDivision of Immunology, Department of Biology, University of Konstanz, Konstanz, Baden-Württemberg, Germany.
Gerardo Omar Alvarez SalinasDivision of Immunology, Department of Biology, University of Konstanz, Konstanz, Baden-Württemberg, Germany.
Gunter SchmidtkeDivision of Immunology, Department of Biology, University of Konstanz, Konstanz, Baden-Württemberg, Germany.
Michael BaslerDivision of Immunology, Department of Biology, University of Konstanz, Konstanz, Baden-Württemberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ubiquitin-like modifier FAT10 is strongly expressed in dendritic cells (DCs) and upregulated during inflammation. Interleukin (IL)-12 plays a critical role in promoting CD4+ T cell differentiation into Th1 cells and in IFN-γ induction in T cells. Previously, it was shown that FAT10 is required for IFN-γ expression of activated T cells. In this study, we investigated whether FAT10 influences IL-12 expression or IL-12 induced signaling and thereby contributes to the reduced IFN-γ expression. Presence or absence of FAT10 did not alter IL-12 expression in DC2.4 cells and in bone marrow derived DCs. Furthermore, FAT10 had no influence on the differentiation of naïve T helper cells to Th1 cells under Th1 polarizing conditions. Additionally, FAT10 did not alter STAT4 phosphorylation in IL-12 receptor stimulated T cells. Taken together, FAT10 neither influences IL-12 expression in DCs nor affects IL-12 receptor signaling in T cells. Hence, the previously observed influence of FAT10 on IFN-γ secretion is not mediated by IL-12.

Indexed as

Interleukin-12Signal TransductionUbiquitinsAnimalsCell DifferentiationDendritic CellsGene Expression RegulationInterferon-gammaMiceMice, Inbred C57BLPhosphorylationReceptors, Interleukin-12STAT4 Transcription FactorTh1 CellsFAT10 protein, mouseInterferon-gammaInterleukin-12Receptors, Interleukin-12STAT4 Transcription FactorUbiquitins

Identifiers

PMID40327681
PMCPMC12054880

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.