Evidence map›Paper›PMID 40327506›Full record

ArticleCell reports2025

SIV proviruses seeded later in infection are harbored in short-lived CD4

Narmada Sambaturu, Emily J Fray, Vivek Hariharan, Fengting Wu, Carolin Zitzmann, Francesco R Simonetti, Dan H Barouch, Janet D Siliciano, Robert F Siliciano, Ruy M Ribeiro and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Narmada SambaturuTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA; School of Systems Science and Industrial Engineering, State University of New York at Binghamton, Binghamton, NY, USA.
Emily J FrayDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Vivek HariharanDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Fengting WuDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Carolin ZitzmannTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Francesco R SimonettiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dan H BarouchCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Janet D SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA.
Ruy M RibeiroTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Alan S PerelsonTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Carmen Molina-ParísTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Thomas LeitnerTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Electronic address: tkl@lanl.gov.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Consortia for Innovative AIDS Research in Nonhuman PrimatesUM1AI124377 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., PICKER, LOUIS J. · 2016 to 2021
$53.0M
Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney CollaboratoryUM1AI164566 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Ann M Chahroudi, Deborah Persaud · 2021 to 2026
$35.5M
Reversing Immune Dysfunction for HIV-1 EradicationUM1AI164561 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SUMIT K CHANDA, Paula M Cannon · 2021 to 2026
$30.0M
I4C 2.0: Immunotherapy for CureUM1AI164556 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Dan H. Barouch, John W Mellors · 2021 to 2026
$28.0M
Project 2U19AI128751 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H. · 2018 to 2022
$14.0M
Reconstructing HIV Epidemics from HIV PhylogeneticsR01AI087520 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI Thomas K. Leitner · 2010 to 2026
$11.2M
Understanding reservoir dynamics through analysis of viral decay processesP01AI169615 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ROBERT F SILICIANO · 2022 to 2026
$9.5M
Modeling Viral and T Lymphocyte DynamicsR01OD011095 · OD · TRIAD NATIONAL SECURITY, LLC · PI PERELSON, ALAN S · 2012 to 2024
$5.0M
Single-Cell Analysis of the HIV/SIV ReservoirR01AI149670 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., SHALEK, ALEX K · 2020 to 2024
$4.6M
Immune System Modeling/HIVR01AI028433 · NIAID · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 1990 to 2021
$3.7M
Investigating antigen-driven clonal proliferation to target HIV-1 persistenceDP5OD031834 · OD · JOHNS HOPKINS UNIVERSITY · PI SIMONETTI, FRANCESCO ROBERTO · 2021 to 2025
$2.0M
NIAID NIH HHS P01 AI169615NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI028433NIAID NIH HHS R01 AI087520NIAID NIH HHS R01 AI149670NIAID NIH HHS U19 AI128751NIAID NIH HHS UM1 AI124377NIAID NIH HHS UM1 AI164556NIAID NIH HHS UM1 AI164561NIAID NIH HHS UM1 AI164566NIH HHS DP5 OD031834NIH HHS R01 OD011095
6 · The paper itself

Abstract

The human immunodeficiency virus (HIV) can persist in a latent form as integrated DNA (provirus) in resting CD4

Indexed as

CD4-Positive T-LymphocytesProvirusesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsHumansMacaca mulattaMutationPhylogenyVirus Integrationantiviral treatmentCP: Microbiologygenetic divergenceHIVlatencySIV

Identifiers

PMID40327506
PMCPMC12160121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.