Evidence map›Paper›PMID 40327267›Full record

ArticleAIDS and behavior2025

Neighborhood Disadvantage, Syndemic Conditions, and PrEP Non-Adherence in Young Sexual and Gender Minority Men.

Michael P Williams, Justin Manjourides, Louisa H Smith, Crissi B Rainer, Lisa Hightow-Weidman, Danielle F Haley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael P WilliamsCenter for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, Boston, MA, USA. mwilliams116@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-3121-2204
Justin ManjouridesBouve College of Health Sciences, Northeastern University, Boston, MA, USA.
Louisa H SmithRoux Institute, Northeastern University, Portland, ME, USA.
Crissi B RainerCollege of Nursing, Florida State University, Tallahassee, FL, USA.
Lisa Hightow-WeidmanCollege of Nursing, Florida State University, Tallahassee, FL, USA.
Danielle F HaleyDepartment of Community Health Sciences, Boston University, Boston, MA, USA.

Funding

The UNC/Emory Center for Innovative Technology (iTech) across the prevention and care continuumU19HD089881 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HIGHTOW-WEIDMAN, LISA B, SULLIVAN, PATRICK SEAN · 2016 to 2022
$35.8M
Bridging the Science-to-Service Gap in Aging Care: Prevention, Optimization and Living Well with Persistent or Serious IllnessesT32AG081327 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie, Ana-Maria Vranceanu · 2023 to 2026
$1.6M
Neighborhood and digital immersion effects on PrEP adherence through a digital intervention in young sexual and gender minorities who have sex with menF31HD108046 · NICHD · NORTHEASTERN UNIVERSITY · PI WILLIAMS, MICHAEL PATRICK · 2022 to 2024
$103k
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5F31HD108046NIA NIH HHS 1T32AG081327NIA NIH HHS T32 AG081327NICHD NIH HHS F31 HD108046NICHD NIH HHS U19 HD089881
6 · The paper itself

Abstract

Adherence to Pre-Exposure Prophylaxis (PrEP) among young sexual and gender minority men who have sex with men (YSGMMSM) has been suboptimal for reducing HIV incidence in the United States. Using the syndemic framework, the present study characterized how neighborhood disadvantage and clustering of two or more syndemic conditions (depression, anxiety, polysubstance use, history of arrest, BIPOC racial identity, unemployment) was related to PrEP non-adherence among 212 YSGMMSM aged 16-24. This study is a secondary analysis of an efficacy trial testing a PrEP adherence digital intervention for YSGMMSM combining participant survey and biological PrEP adherence data with measures of neighborhood disadvantage. Using multilevel models, we found that YSGMMSM residing in high-disadvantage neighborhoods were 2.79 (CI = 1.11, 7.00) times more likely to have a cluster of syndemic conditions compared to those in low-disadvantage neighborhoods. YSGMMSM residing in high-disadvantage neighborhoods were 3.14 (OR = 3.14, CI = 1.17, 8.44) times more likely to be PrEP non-adherent. YSGMMSM with two or more syndemic conditions were 2.64 (CI = 1.01, 6.94) times more likely to be PrEP non-adherent compared to those with 0 or 1 condition. Among participants living in high-disadvantage neighborhoods, 38% had a cluster of a syndemic conditions compared 20% in low-disadvantage neighborhoods. Despite this, neighborhood disadvantage did not significantly moderate the relationship between clustering of syndemic conditions and PrEP non-adherence among YSGMMSM. Further research into multilevel syndemic influences on PrEP adherence is needed to develop strategies for improving HIV vulnerability among YSGMMSM.

Indexed as

Anti-HIV AgentsHIV InfectionsHomosexuality, MaleMedication AdherenceNeighborhood CharacteristicsPre-Exposure ProphylaxisResidence CharacteristicsSexual and Gender MinoritiesSyndemicAdolescentAdultHumansMaleSubstance-Related DisordersUnited StatesYoung AdultAnti-HIV AgentsHIV preventionNeighborhood effectsPrEP adherenceStructural disparitiesSyndemics

Identifiers

PMID40327267
PMCPMC12522209

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.