Evidence map›Paper›PMID 40327258›Full record

ArticleSpine deformity2025

Comparative analysis of thoracic structure and function using CT and dynamic MRI in pediatric thoracic insufficiency syndrome with and without neuromuscular disease.

Sara Hassani, Yubing Tong, Nima Broomand Lomer, Jayaram K Udupa, Caiyun Wu, Joseph M McDonough, Samantha Gogel, Oscar H Mayer, David M Biko, Patrick J Cahill and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Spine deformity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sara HassaniMedical Image Processing Group, Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Yubing TongMedical Image Processing Group, Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Nima Broomand LomerMedical Image Processing Group, Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Jayaram K UdupaMedical Image Processing Group, Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Caiyun WuMedical Image Processing Group, Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Joseph M McDonoughThe Wyss/Campbell Center for Thoracic Insufficiency Syndrome, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Samantha GogelThe Wyss/Campbell Center for Thoracic Insufficiency Syndrome, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Oscar H MayerThe Wyss/Campbell Center for Thoracic Insufficiency Syndrome, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
David M BikoThe Wyss/Campbell Center for Thoracic Insufficiency Syndrome, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Patrick J CahillThe Wyss/Campbell Center for Thoracic Insufficiency Syndrome, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Jason B AnariThe Wyss/Campbell Center for Thoracic Insufficiency Syndrome, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Drew A TorigianMedical Image Processing Group, Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. drew.torigian@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-8999-9735

Funding

Foundation for the National Institutes of Health R01HL150147
6 · The paper itself

Abstract

purposeThoracic insufficiency syndrome (TIS) impairs normal respiration and lung growth. In pediatric patients with or without neuromuscular disease (NMD), the relationship between thoracic structure and regional respiratory function remains understudied. We aimed to evaluate these interrelationships using dynamic magnetic resonance imaging (dMRI) and computed tomography (CT).

methodsThis study included 25 pediatric TIS patients: 8 with NMD and 17 without NMD. Thoracic dMRI and CT images were analyzed to quantify intercostal muscle (ICM) volume, skeletal muscle (SM) volume, lung volumes at end-inspiration and end-expiration, chest wall excursion volume, and diaphragm excursion volume. Right-to-left volumetric symmetry ratios were compared using unpaired t-testing, and correlations between structural and functional parameters were assessed using Pearson correlation analysis.

resultsLung and muscle volumes were generally larger in the TIS-NMD compared to TIS non-NMD, reflecting age-related differences, although lung tidal volumes and diaphragmatic and chest wall excursion volumes were generally similar. The degree of asymmetry reflected by diaphragmatic respiratory function symmetry ratios exceeded that of chest wall symmetry ratios in both groups, with greater disparity in TIS-NMD (3.6 vs 1.8 in TIS-NMD compared to 2.8 vs 2.5 in TIS non-NMD). Correlation between thoracic SM volume and tidal volume was stronger than the correlation between ICM volume and tidal volume in both groups. TIS-NMD patients demonstrated unique compensatory dynamics, including a negative correlation between SM volume and diaphragmatic excursion volume.

conclusionDistinct interrelationships exist between thoracic structure and function in TIS patients with and without NMD. These findings suggest that NMD significantly influences respiratory mechanics, emphasizing the role of SM and diaphragm interaction.

Indexed as

Magnetic Resonance ImagingNeuromuscular DiseasesRespiratory InsufficiencyThoraxTomography, X-Ray ComputedAdolescentChildChild, PreschoolDiaphragmFemaleHumansInfantLungMaleThoracic WallComputed tomographyDynamic magnetic resonance imagingNeuromuscular diseaseThoracic insufficiency syndrome

Identifiers

PMID40327258

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.