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ArticleInternational urology and nephrology2025

Deciphering the urinary microRNAs landscape in nephrotic syndrome: implications as prognostic marker-a non-invasive study.

Pricilla Charmine, Vettriselvi Venkatesan, Sangeetha Geminiganesan, Sudha Ekambaram, B R Nammalwar, R P Parameswari, C D Mohana Priya

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Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pricilla CharmineFaculty of Clinical Research, SRIHER, No.1 Ramachandra Nagar, Porur, Chennai, 600116, India.ORCID http://orcid.org/0000-0002-0974-2241
Vettriselvi VenkatesanDepartment of Human Genetics, SRIHER, No.1 Ramachandra Nagar, Porur, Chennai, 600116, India.ORCID http://orcid.org/0000-0003-2827-8680
Sangeetha GeminiganesanDepartment of Paediatric Nephrology, Kauvery Hospital Chennai - Radial Road, No. 2/473, Radial Road, Kovilambakkam, Chennai, 600 129, India.ORCID http://orcid.org/0000-0003-0734-1126
Sudha EkambaramPediatric Nephrologist, Greams Lane, 21, Greams Road, Thousand Lights West, Thousand Lights, Chennai, Tamil Nadu, 600006, India.ORCID http://orcid.org/0000-0001-9971-1344
B R NammalwarDr. Mehta's Hospital, No.2/1,2, 3, Mc Nichols Road 3rd Ln, Chetpet, Chennai, Tamil Nadu, 600031, India.
R P ParameswariSaveetha University, Thandalam, Kanchipuram - Chennai Road, Chennai, Tamil Nadu, 602105, India.
C D Mohana PriyaDepartment of Human Genetics, SRIHER, No.1 Ramachandra Nagar, Porur, Chennai, 600116, India. mohanapriya@sriramachandra.edu.in.ORCID http://orcid.org/0000-0001-6760-785X

Funding

Department of Biotechnology, Ministry of Science and Technology, India Ref No: BT/PR30523/ BIC/101/1121/2018
6 · The paper itself

Abstract

Nephrotic syndrome is a complex renal condition characterized by abnormal protein permeability into the urine space, leading to edema and renal failure. Recent research suggests that deregulation of microRNAs contributes to the pathogenesis of this disease. MicroRNAs are small, non-coding RNA molecules that regulate gene expression by binding to complementary messenger RNA sequences. In this study, we employed bioinformatics techniques to analyze microRNA expression in urine samples from nephrotic syndrome patients and healthy control participants. Our results revealed a significant disruption of microRNA expression profiles in patients with nephrotic syndrome, indicating that these microRNAs may play a crucial role in the disease. This study highlights the potential of urinary microRNAs as biomarkers for nephrotic syndrome and warrants further investigation into their functional significance in the disease pathogenesis.

Indexed as

MicroRNAsNephrotic SyndromeAdultBiomarkersCase-Control StudiesComputational BiologyFemaleHumansMaleMiddle AgedPrognosisBiomarkersMicroRNAsBioinformaticsmicroRNAmiRDatabase2.0Nephrotic syndromeROC analysis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.