Evidence map›Paper›PMID 40327129›Full record

ReviewMolecular biology reports2025

MicroRNAs modulation by curcumin, catalpol, and other natural products in Alzheimer's disease: a review.

Amir Modarresi Chahardehi, Reza Arefnezhad, Alireza Pourbafrani, Leila Tajik, Seyed Aref Asadi, Hossein Salehi, Saba Yazdanian, Asma Nakhaee, Mehrzad Sepahi Esfahani, Parnian Behzad and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Amir Modarresi ChahardehiCoenzyme R Research Institute, Tehran, Iran.
Reza ArefnezhadCoenzyme R Research Institute, Tehran, Iran.
Alireza PourbafraniDepartment of Motor Behavior, Faculty of Physical Education, Allameh Tabatbai University, Tehran, Iran.
Leila TajikFaculty of Medicine, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
Seyed Aref AsadiBirjand University of Medical Sciences, Birjand, Iran.
Hossein SalehiDepartment of Physiology, Tehran University of Medical Sciences, Tehran, Iran.
Saba YazdanianHamedan University of Medical Sciences, Hamedan, Iran.
Asma NakhaeeMashhad University of Medical Sciences, Mashhad, Iran.
Mehrzad Sepahi EsfahaniShahid Sadoughi University of Medical Sciences, Yazd, Iran.
Parnian BehzadScience and Research Branch, Islamic Azad University, Tehran, Iran.
Helia HaghaniCoenzyme R Research Institute, Tehran, Iran.
Zahra NiknamNeurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran. niknam_zahra@yahoo.com.
Niloofar SefatiDepartment of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran. N.sefati@arakmu.ac.ir.
Fatemeh Rezaei-TazangiDepartment of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran. f.rezaei67@yahoo.com.
Marziye Ranjbar TavakoliPharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited pharmacological treatment options, necessitating the exploration of alternative therapeutic strategies. Emerging evidence suggests that microRNAs (miRNAs), such as miR-132, miR-34a, and miR-124, play crucial roles in AD pathogenesis, influencing amyloid-beta (Aβ) aggregation, tau phosphorylation, neuroinflammation, and oxidative stress. Natural products have been identified as potential modulators of miRNA expression, offering neuroprotective benefits through multi-target mechanisms. This review systematically examines the impact of curcumin, catalpol, Allium jesdianum, Tanshinone IIA (Tan IIA), and Tiaoxin Recipe (TXR) on miRNA regulation in AD, summarizing their molecular targets and therapeutic potential. Furthermore, we discuss challenges related to bioavailability and clinical translation, highlighting the need for advanced delivery systems and personalized medicine approaches. By integrating recent findings, this review provides a comprehensive perspective on the role of miRNA modulation in AD therapy and underscores the potential of natural products as novel therapeutic agents.

Indexed as

Alzheimer DiseaseBiological ProductsCurcuminIridoid GlucosidesMicroRNAsAmyloid beta-PeptidesAnimalsHumansNeuroprotective AgentsOxidative StressAmyloid beta-PeptidesBiological ProductscatalpolCurcuminIridoid GlucosidesMicroRNAsNeuroprotective AgentsAllium jesdianumAlzheimer's diseaseCatalpolCurcuminMicroRNANatural productsNeuroprotectionOxidative stressTanshinone IIATiaoxin recipe

Identifiers

PMID40327129

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.