Neuromodulation by repetitive paired-pulse TMS at late I-wave intervals in older adults.

Wei-Yeh Liao, Brodie J Hand, Giuseppe Rinaldi, John G Semmler, George M Opie

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Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Wei-Yeh LiaoDiscipline of Physiology, School of Biomedicine, The University of Adelaide, Adelaide, Australia. wei-yeh.liao@adelaide.edu.au.ORCID http://orcid.org/0000-0002-8912-9796

Brodie J HandDiscipline of Physiology, School of Biomedicine, The University of Adelaide, Adelaide, Australia.

Giuseppe RinaldiDiscipline of Anatomy and Pathology, School of Biomedicine, The University of Adelaide, Adelaide, Australia.

John G SemmlerDiscipline of Physiology, School of Biomedicine, The University of Adelaide, Adelaide, Australia.

George M OpieDiscipline of Physiology, School of Biomedicine, The University of Adelaide, Adelaide, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of indirect (I) wave periodicity repetitive transcranial magnetic stimulation (iTMS) on the excitability of primary motor cortex (M1) in young adults can be modified by changing the late I-wave interval. Given that late I-wave activity is altered in older adults, this could contribute to age-related changes in M1 plasticity. To assess this possibility, the present study investigated the effects of iTMS using three late I-wave intervals (4.0, 4.5, and 5.0 ms) on M1 excitability in 17 older adults (69.6 ± 5.7 years; 10 females), which was compared to findings obtained previously in 17 young adults (27.2 ± 6.4 years, 12 females). Changes in M1 excitability were assessed using motor evoked potentials (MEPs) recorded from the right first dorsal interosseus to index single-pulse MEP

Indexed as

AgingEvoked Potentials, MotorMotor CortexTranscranial Magnetic StimulationAdultAgedElectromyographyFemaleHumansMaleMiddle AgedYoung AdultAgeingPlasticityPrimary motor cortexTranscranial magnetic stimulation

Identifiers

PMID40327107

DOI10.1016/j.brs.2008.06.006

PMCPMC12055644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.