Evidence map›Paper›PMID 40327098›Full record

ArticleAnnals of hematology2025

Germline mutations predispose a concurrent thymoma and diffuse large B-cell lymphoma.

Xiaoyan Fu, Qiao Jiang, Wenbin Mo, Jinjing Zhang, Yan Li, Yuan Miao, Rui Zhang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyan FuDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Qiao JiangDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Wenbin MoDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Jinjing ZhangDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yan LiDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yuan MiaoDepartment of Pathology, The College of Basic Medical Sciences and The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Rui ZhangDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China. hemozerro2008@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although thymoma is a rare malignancy, it is usually accompanied by secondary cancers. Non-Hodgkin's B-cell lymphoma is one of the most common secondary neoplasms observed in patients with thymoma, presenting before, concurrently with, or after the diagnosis. However, the underlying molecular mechanism of concomitant thymoma and lymphoma remains unclear. This study aimed to report a case with concurrent extrathymic, diffuse large B-cell lymphoma (DLBCL), and thymoma. Published studies and the SEER database were queried to summarize the features of patients with these concomitant cancers. Whole-exome sequencing (WES) was performed on tumor specimens and buccal swab mucosa. Six germline mutations and several specific somatic alterations were found on each neoplastic tissue, which may elucidate the potential pathogenesis of concurrent cancers. This study was novel in reporting concurrent extrathymic DLBCL and thymoma by applying WES on matched neoplasm-normal samples to explore the pathogenesis of these distinct neoplasms.

Indexed as

Genetic Predisposition to DiseaseGerm-Line MutationLymphoma, Large B-Cell, DiffuseNeoplasms, Multiple PrimaryThymomaThymus NeoplasmsExome SequencingHumansDLBCLGermline mutationSomatic mutationThymomaWhole-exome sequencing

Identifiers

PMID40327098
PMCPMC12283472

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.