ArticleEuropean journal of nuclear medicine and molecular imaging2025
Evidence for brain glial activity in chronic migraine patients: a [
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- Review
- Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.Brain : a journal of neurology · 2026Review
- Targeting glial-orchestrated neuroinflammation in migraine pathophysiology.The journal of headache and pain · 2026Review
- HIF-1 Targeting Intervention Renders Protection From Alzheimer's-Like Pathology in a Humanized Mice Model of HIV Infection.Journal of extracellular vesicles · 2025Article
- Disrupted functional connectivity in the hippocampal subregions of patients with migraine without aura: a functional study on mechanisms underlying migraine chronification.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
purposeAlthough neuroinflammation may play a key role in the pathology of migraine and its progression to chronic migraine (CM), its specific involvement-particularly the role of microglia- remains unclear. We investigated whether neuroinflammation is involved in the pathophysiology of CM and whether pro-inflammatory signals are associated with its clinical features.
methodsNineteen individuals with CM and 10 healthy controls (HCs) underwent integrated brain positron emission tomography (PET)/magnetic resonance (MR) using the translocator protein (TSPO) radioligand ([
resultsCM patients had a significantly higher Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) scores than that in HCs (p < 0.05). Participants with CM also exhibited reduced volume in the thalamus (p = 0.012), compared with HCs. Moreover [11C] PBR28 binding was increased in the midbrain, occipital lobe and vermis, along with increased interictal plasma interleukin-8 (IL-8) and CX3CL1 levels, in individuals with CM compared with HCs. Notably, the midbrain levels of TSPO were negatively correlated with the headache frequency (r=-0.462, p = 0.046).
conclusionsThese findings demonstrate increased central inflammation in CM participants compared to HCs, providing imaging evidence for the potential involvement of neuroinflammation in CM pathophysiology. Additionally, the observed reduction in thalamic volume may contribute to the chronification of migraine. CLINICAL TRIAL NUMBER: Not applicable.
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