Evidence map›Paper›PMID 40327008›Full record

ArticleChembiochem : a European journal of chemical biology2025

Preorganized Electric Fields in Voltage-Gated Sodium Channels.

Yi Zheng, Taoyi Chen, Valerie Vaissier Welborn

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yi ZhengDepartment of Chemistry, Virginia Tech, Blacksburg, VA, 24061, USA.
Taoyi ChenDepartment of Chemistry, Virginia Tech, Blacksburg, VA, 24061, USA.
Valerie Vaissier WelbornDepartment of Chemistry, Virginia Tech, Blacksburg, VA, 24061, USA.ORCID https://orcid.org/0000-0003-0834-4441

Funding

Lay Nam Chang Dean's Discovery FundVirginia Tech Department of Chemistry Faculty Start-up Funds
6 · The paper itself

Abstract

Enzymes are reported to catalyze reactions by generating electric fields that promote the evolution of the reaction in the active site. Although seldom used outside enzymatic catalysis, electrostatic preorganization theory and language of electric fields can be generalized to other biological macromolecules. Herein, we performed molecular dynamics simulations of human Na

Indexed as

NAV1.5 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelVoltage-Gated Sodium ChannelsHumansMolecular Dynamics SimulationSodiumStatic ElectricityNAV1.5 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelSodiumVoltage-Gated Sodium Channelselectric fieldselectrostatic preorganizationsmutual informationpolarizable force fieldsvoltage‐gated ion channels

Identifiers

PMID40327008
PMCPMC12117427

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.