SynthesisThe British journal of surgery2025
Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective.
Synthesis in The British journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Salvage surgery for free flap failure in the maxillofacial region: a comprehensive review of principles and outcomes.Annals of medicine and surgery (2012) · 2026Article
- [Analysis of factors influencing tension blister formation on the skin at the dressing edges in patients undergoing negative pressure wound therapy].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Advanced Grafting Biomaterials and Technologies in Chronic Wound Care: Mechanisms, Clinical Outcomes, and Therapeutic Integration.Journal of functional biomaterials · 2026Review
- Comparison of treatment approaches for mediastinitis after coronary artery bypass grafting: Negative pressure wound therapy versus conventional methods.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Negative pressure wound therapy: does it suck?The British journal of surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundNegative pressure wound therapy (NPWT) has been used in clinical practice for surgical wounds healing by secondary intention (SWHSI), despite limited evidence regarding its clinical effectiveness and cost-effectiveness. The aim of this study was to evaluate the cost-effectiveness of NPWT for SWHSI, compared with standard dressings, from the perspective of the UK healthcare system.
methodsAn economic model was used to extrapolate the effectiveness results of a meta-analysis over a patient's lifetime and estimate the costs and outcomes (quality-adjusted life-years (QALYs)) of NPWT and standard dressings. The probability of NPWT being cost-effective was estimated, with extensive scenario analyses conducted to evaluate the robustness of results and the degree of uncertainty.
resultsOn average, NPWT was associated with higher costs and marginally higher QALYs than standard dressings. The cost difference was mainly driven by the additional intervention costs associated with NPWT. The estimated probability of NPWT being cost-effective was <30%. There was considerable uncertainty in the findings, driven largely by uncertainty in the estimated pooled relative effect from the meta-analysis. Results were robust to different scenario analyses.
conclusionNo evidence was found demonstrating that NPWT was a cost-effective alternative to standard dressings for SWHSI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.