ReviewAngewandte Chemie (International ed. in English)2025
Mechanochemical Strategies Applied to the Late-Stage Modifications of Pharmaceutically Active Compounds.
Review in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations.Angewandte Chemie (International ed. in English) · 2026Review
- Machine learning-assisted development of a fast Mechanochemical Johnson-Corey-Chaykovsky reaction.Nature communications · 2026Article
- Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Experimental Isolation of Single Impact, Cumulative Energy, Aging, and Liquid-Assisted Grinding Effects in Mechanochemical Reactions.Angewandte Chemie (International ed. in English) · 2026Article
- Mechanochemical Strategies Applied to the Late-Stage Modifications of Pharmaceutically Active Compounds.Angewandte Chemie (International ed. in English) · 2025Review
- Solventless Catalytic C-H and C-X Functionalization without Ball Milling.The Journal of organic chemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This review explores the potential of mechanochemistry in the late-stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds by examining the scope, efficiency, and mechanistic aspects of these approaches. To further assist researchers, we provide a detailed table summarizing the discussed APIs, their respective modifications, and any necessary prefunctionalizations. This resource should provide a practical guide for selecting suitable substrates to evaluate the pharmaceutical relevance of existing and novel (mechano)chemical methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.