Trial reportPaediatric anaesthesia2025
Perioperative Intravenous Lidocaine Infusion Therapy as an Adjunct to Multimodal Analgesia for Adolescent Idiopathic Scoliosis Surgical Correction: A Double-Blind Randomized Controlled Trial.
Trial report in Paediatric anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04069169 (Perioperative Multimodal Analgesia Including Intravenous Lidocaine Infusion for Pain Management Following Idiopathic Scoliosis Correction Surgery in Children), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perioperative Multimodal Analgesia Including Intravenous Lidocaine Infusion for Pain Management Following Idiopathic Scoliosis Correction Surgery in Children
Who cites it
3 citing papers in PubMed.
- Intraoperative Lidocaine Infusion Therapy and Neurophysiological Monitoring in Adolescents Undergoing Idiopathic Scoliosis Correction: A Supplemental Analysis of a Prospective Study.Paediatric anaesthesia · 2026Article
- Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population-A Scoping Review.Paediatric anaesthesia · 2026Article
- Postoperative pain management in children.Frontiers in pediatrics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundPosterior spinal instrumentation and fusion is a common surgical correction for adolescent idiopathic scoliosis. Preventative multimodal analgesia, including opioids, is required to minimize postoperative pain, but opioids are associated with dose-dependent side effects that may disrupt recovery.
aimsWe hypothesized that the addition of 48-h perioperative intravenous lidocaine therapy to a multimodal analgesia regimen would reduce morphine utilization.
methodWe conducted a double-blinded randomized controlled trial in 10-19 years old, ASA I-III, undergoing single-stage scoliosis correction. Participants were randomly allocated to the Intervention group (intravenous lidocaine 1 mg kg
resultsData were available from 38 participants: 32 (84%) female; median (IQR) age 16.3 (14.9-17.2) years, with curve magnitude (Cobb angle) 62 (56-70) degrees. The 48-h morphine utilization did not differ between groups: Intervention median (IQR) 0.86 (0.73-1.05) mg kg
conclusionsWe found no evidence to support the adjunctive use of 48-h perioperative intravenous lidocaine therapy in adolescents undergoing scoliosis correction in which effective multimodal analgesia was adopted.
trial registrationClinicalTrials.gov identifier: NCT04069169.
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Registered trials
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