Evidence map›Paper›PMID 40326605›Full record

Trial reportThe journals of gerontology. Series B, Psychological sciences and social sciences2025

Perceived Control, Cognitive Training, and Incident Alzheimer's Disease and Related Dementias in the ACTIVE Study.

Laura B Zahodne, Katherine Miller, Chuxuan Sun, Neika Sharifian, Jeanine M Parisi, George W Rebok, Adrienne T Aiken-Morgan, Alden L Gross, Kelsey R Thomas, Cynthia Felix and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series B, Psychological sciences and social sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura B ZahodneDepartment of Psychology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-5763-4501
Katherine MillerDepartment of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-6726-2369
Chuxuan SunDepartment of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0009-0008-3496-1586
Neika SharifianDepartment of Psychology, University of Michigan, Ann Arbor, Michigan, USA.
Jeanine M ParisiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
George W RebokDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Adrienne T Aiken-MorganDepartment of Psychiatry, University of North Carolina at Chapel Hill - School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0001-7069-9601
Alden L GrossDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Kelsey R ThomasResearch Service, VA San Diego Healthcare System, San Diego, California, USA.ORCID 0000-0003-4277-8876
Cynthia FelixUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Norma B CoeDepartment of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1228-0938

Funding

Resilience Mechanisms Underlying Racial/Ethnic Disparities in Alzheimer’s DiseaseR01AG054520 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, ZAHODNE, LAURA B · 2017 to 2021
$5.8M
Mechanisms of inequalities in ADRD risk across race and place in the Michigan Cognitive Aging ProjectR01AG082307 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Laura B Zahodne · 2023 to 2026
$3.8M
Heterogeneity of subtle cognitive decline phenotypes in community-dwelling older adultsRF1AG082726 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kelsey R Thomas · 2023 to 2026
$3.3M
Intersection of Physiologic Frailty and Cognitive Performance in Older Adults: An Integrative Data AnalysisK01AG050699 · NIA · JOHNS HOPKINS UNIVERSITY · PI GROSS, ALDEN L. · 2016 to 2020
$648k
Alzheimer's Association AARG-22-723000CSRD VA IK2 CX001865Indiana University School of Medicine U01 NR04508Johns Hopkins University U01 AG14260National Institute of Nursing Research to Hebrew Senior Life U01 NR04507New England Research Institutes U01 AG14282NIANIA NIH HHS K01 AG050699NIA NIH HHS R01 AG054520NIA NIH HHS R01 AG082307NIA NIH HHS RF1 AG082726Pennsylvania State University U01 AG14263University of Alabama at Birmingham U01 AG14289University of Florida U01 AG14276U.S. Department of Veterans Affairs
6 · The paper itself

Abstract

objectivesGreater perception of control over important life outcomes has been linked to better cognitive performance and greater benefits from cognitive training interventions among older adults. However, it is not yet known whether perceived control predicts incident Alzheimer's disease and related dementias (ADRD) or influences links between cognitive training and ADRD incidence.

methodsData were obtained from 2,021 participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial. Baseline perceived control was measured with the Personality in Intellectual Aging Contexts Inventory. Incident diagnosed ADRD over 20 years was operationalized using Centers for Medicare and Medicaid Services claims data. Main effects of perceived control and interactions between perceived control and intervention group (reasoning, memory, speed, control) on diagnosed ADRD incidence were estimated using cause-specific hazard models.

resultsGreater perceived control at study baseline was associated with reduced hazard of ADRD. Perceived control did not moderate associations between intervention group and time to ADRD diagnosis. DISCUSSION: Strengthening perceived control through individual and/or environmental interventions may lower ADRD risk.

Indexed as

Alzheimer DiseaseDementiaAgedAged, 80 and overCognitive TrainingFemaleHumansIncidenceMaleUnited StatesDementiaLocus of controlPrevention

Identifiers

PMID40326605
PMCPMC12343038

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.