Evidence map›Paper›PMID 40326601›Full record

ArticleThe Cochrane database of systematic reviews2025

Sedation for moderate-to-severe traumatic brain injury in adults.

David R Williamson, Lindsay Dryden, Wei Cheng, Brian Hutton, Becky Skidmore, Sangeeta Mehta, Eyal Golan, Alexis F Turgeon, Neill Kj Adhikari, Louise Rose and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Cochrane database of systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David R WilliamsonFaculty of Pharmacy / Department of Pharmacy, Université de Montréal / Hôpital du Sacré-Coeur de Montréal, Montréal, Canada.
Lindsay DrydenLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
Wei ChengYale School of Public Health, Yale University, New Haven, USA.
Brian HuttonKnowledge Synthesis Group, Ottawa Hospital Research Institute, Ottawa, Canada.
Becky SkidmoreOttawa, Canada.
Sangeeta MehtaInterdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Eyal GolanDepartment of Medicine, University Health Network, Toronto, Canada.
Alexis F TurgeonDepartment of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Faculty of Medicine, Université Laval, Québec City, Canada.
Neill Kj AdhikariInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Louise RoseFlorence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.
Lisa BurryDepartment of Pharmacy, Mount Sinai Hospital, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of sedative, analgesic, and anaesthetic drugs on neurological outcomes in adults with moderate-to-severe traumatic brain injury.

Indexed as

Brain Injuries, TraumaticHypnotics and SedativesProcedural SedationAdultAnalgesicsAnestheticsHumansRandomized Controlled Trials as TopicSystematic Reviews as TopicAnalgesicsAnestheticsHypnotics and Sedatives

Identifiers

PMID40326601
PMCPMC12053465

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.