Evidence map›Paper›PMID 40326516›Full record

ArticleNucleic acids research2025

StructMAn 2.0 Web: a web server for structural annotation of protein sequences and mutations.

Alper Yurtseven, Sebastian Keller, Pascal Hirsch, Olga V Kalinina, Alexander Gress

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alper YurtsevenResearch Group Drug Bioinformatics, Department Drug Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Saarland, Germany.ORCID 0009-0002-8133-9403
Sebastian KellerResearch Group Drug Bioinformatics, Department Drug Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Saarland, Germany.ORCID 0000-0003-4182-5474
Pascal HirschChair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Saarland, Germany.ORCID 0000-0003-4152-9931
Olga V KalininaResearch Group Drug Bioinformatics, Department Drug Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Saarland, Germany.ORCID 0000-0002-9445-477X
Alexander GressResearch Group Drug Bioinformatics, Department Drug Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Saarland, Germany.ORCID 0000-0001-9554-805X

Funding

BMBF 01ZX1908CDrugSiderAI 031L0306AHelmholtzAI projectHelmholtz Centre for Infection ResearchKlaus Faber Foundation
6 · The paper itself

Abstract

StructMAn is a method for protein structural annotation. It describes each position of a protein sequence or specific variants in it in terms of their importance for the three-dimensional (3D) structure of the protein and its interactions with other molecules. StructMAn maps, aligns, and aggregates data from experimentally resolved and predicted 3D structures of proteins and their homologs for any given protein sequence and/or a combination of mutations in it. The results provide structural annotation for every amino acid position allowing a detailed structural analysis. Furthermore, StructMAn enables generation of a wide variety of position-specific high-quality structural features that can be leveraged in machine learning applications. With the new web server StructMAn 2.0 Web, we provide a user-friendly way to use StructMAn offering an easy-to-use input interface and a comprehensive visualization for the various results of StructMAn. StructMAn 2.0 Web is available at https://tools.helmholtz-hips.de/structman.

Indexed as

Molecular Sequence AnnotationMutationProteinsSoftwareAmino Acid SequenceInternetModels, MolecularProtein ConformationSequence Analysis, ProteinUser-Computer InterfaceProteins

Identifiers

PMID40326516
PMCPMC12230719

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.