Evidence map›Paper›PMID 40326506›Full record

ArticleOral diseases2025

Nanotechnology-Enabled Blood Test for Oral Epithelial Disorders Management: A Proof-of-Concept Study.

Erica Quagliarini, Giulio Caracciolo, Francesca Giulimondi, Federica Rocchetti, Gianluca Tenore, Lucia Borghetti, Laura Ottini, Valentino Valentini, Antonella Polimeni, Umberto Romeo

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In one paragraph

Article in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erica QuagliariniNanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Giulio CaraccioloNanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Francesca GiulimondiNanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Federica RocchettiDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-5912-4812
Gianluca TenoreDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Lucia BorghettiDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Laura OttiniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Valentino ValentiniDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Antonella PolimeniDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Umberto RomeoDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo address the limitations and complexities associated with tissue biopsy, emerging nanotechnology methods show promise in enhancing the detection and management of oral squamous cell carcinoma and oral potential malignant disorders. Among them, the characterization of the protein corona, the biomolecular layer that envelops materials when exposed to biological fluids, has recently emerged as a powerful tool for distinguishing oncological patients from healthy people. MATERIALS AND

methodsBuilding upon recent insights, here we formulated a new diagnostic method for oral squamous cell carcinoma and oral potentially malignant disorders based on the characterization of the personalized protein corona formed on graphene oxide nanosheets when exposed to the plasma of the patients.

resultsThe findings highlighted a discernible distinction between oncological subjects and healthy ones, resulting in an overall accuracy of 87%. Subsequently, we applied this method to monitor the progression of the diseases of the patients undergoing treatment, and we observed a trend indicating a convergence of protein profiles between oncological patients and healthy subjects throughout the treatment course.

conclusionIf further confirmed in larger prospective studies, this new approach could discriminate oral squamous cell carcinoma and oral potentially malignant disorders and can be considered in the management of these oral diseases.

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsNanotechnologyProtein CoronaAgedFemaleGraphiteHumansMaleMiddle AgedProof of Concept Studygraphene oxideGraphiteProtein Coronabiomarkersblood testnanoparticlesoral canceroral potentially malignant disordersprotein corona

Identifiers

PMID40326506
PMCPMC12803622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.