ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Contrast Sensitivity Predicts 30-month Functional Brain Network Integrity in Cognitively Unimpaired Older Adults: the Brain Networks and Mobility Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- IGROOVE: Protocol for a randomized, controlled, single-blind trial of dance intervention in older adults with subjective cognitive decline.Contemporary clinical trials communications · 2026Article
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9 authors.
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Abstract
backgroundVisual contrast sensitivity (CS) is critical to many functions in older adults and is associated with brain network community structure, but the direction of the relationship between CS and the brain remains unclear.
methodsWe evaluated whether baseline binocular CS predicts 30-month functional brain network organization in 172 community-dwelling older adults (mean age 76.4 ± 4.8 years, 56.4% female, 11.6% non-White/Hispanic) that underwent functional MRI at rest and during a motor imagery task. We constructed separate distance regression models for each of the 8 subnetworks covering the entire brain, while controlling for the baseline brain networks, sex, and the number of volumes removed during motion scrubbing from head motion in the scanner.
resultsWorse baseline CS predicted lower community structure integrity at 30 months in the visual network (β = 0.0115; p < .0001), dorsal attention network (β = 0.0075; p = .0089), and default mode network both at rest (β = 0.0173; p < .0001) and during the motor imagery task (default mode network, β = 0.0103; p = .0002). No other networks showed significant associations. The dorsal attention network did not have a relationship with CS at baseline but was significant at 30 months. Similar findings were observed in models that additionally controlled for baseline Montreal Cognitive Assessment and change in Montreal Cognitive Assessment score over 30 months.
conclusionsPoor CS may identify a subset of older adults at risk of future decrements in brain circuits important for vision, cognitive, and mobility functions. Future studies should explore if improving CS increases functional brain health.
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