Evidence map›Paper›PMID 40326341›Full record

ArticleEmerging microbes & infections2025

Effect of mosquito saliva from distinct species on human dermal endothelial cell function

Imke Visser, Vincent Vaes, Peter van Run, Eleanor M Marshall, Lars Vermaat, Charlotte Linthout, Dick H W Dekkers, Jeroen A A Demmers, Marion P G Koopmans, Constantianus J M Koenraadt and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Immunosuppressive impact ofFrontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Imke VisserDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.
Vincent VaesErasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, The Netherlands.
Peter van RunDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.
Eleanor M MarshallDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.
Lars VermaatErasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, The Netherlands.
Charlotte LinthoutDepartment of Entomology, Wageningen University & Research, Wageningen, The Netherlands.
Dick H W DekkersProteomics Center, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jeroen A A DemmersProteomics Center, Erasmus University Medical Center, Rotterdam, the Netherlands.
Marion P G KoopmansDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.
Constantianus J M KoenraadtDepartment of Entomology, Wageningen University & Research, Wageningen, The Netherlands.
Melanie RissmannDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.
Barry RockxDepartment of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During probing and feeding, an infected mosquito injects both virus and saliva into the host skin. The presence of mosquito saliva in the skin increases arbovirus pathogenesis in the bitten host, however the exact mechanism behind this remains to be determined. It is hypothesized that disease enhancement is dependent on the function of the dermal endothelium, where increased permeability aids in the influx of virus-susceptible cells to the bite site and therefore more cells for the virus to replicate in. Here, we investigate the effects of saliva from

Indexed as

AedesCulexEndothelial CellsSalivaWest Nile FeverWest Nile virusAnimalsDisease Models, AnimalFemaleHumansMiceMosquito VectorsSkinArbovirusCulex pipiensmosquito salivapathogenesistransmissionvascular leakageWest Nile virus

Identifiers

PMID40326341
PMCPMC12312492

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.