Evidence map›Paper›PMID 40326329›Full record

ArticleJournal of peptide science : an official publication of the European Peptide Society2025

In Vivo Evaluation of Pam

Salwa Aljohani, Alex G Edmonds, Valeria Castelletto, Jani Seitsonen, Ian W Hamley, Peter Symonds, Victoria A Brentville, Lindy G Durrant, Nicholas J Mitchell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of peptide science : an official publication of the European Peptide Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Salwa AljohaniSchool of Chemistry, University of Nottingham, University Park, Nottingham, UK.
Alex G EdmondsSchool of Chemistry, University of Nottingham, University Park, Nottingham, UK.ORCID https://orcid.org/0009-0005-5139-8666
Valeria CastellettoSchool of Chemistry, Pharmacy and Food Biosciences, University of Reading, Reading, UK.
Jani SeitsonenNanomicroscopy Center, Aalto University, Espoo, Finland.
Ian W HamleySchool of Chemistry, Pharmacy and Food Biosciences, University of Reading, Reading, UK.ORCID https://orcid.org/0000-0002-4549-0926
Peter SymondsScancell, Biodiscovery Institute, University of Nottingham, University Park, Nottingham, UK.
Victoria A BrentvilleScancell, Biodiscovery Institute, University of Nottingham, University Park, Nottingham, UK.
Lindy G DurrantScancell, Biodiscovery Institute, University of Nottingham, University Park, Nottingham, UK.
Nicholas J MitchellSchool of Chemistry, University of Nottingham, University Park, Nottingham, UK.ORCID https://orcid.org/0000-0002-9041-1852

Funding

Leverhulme Trust RPG-2023-22Taibah University, Kingdom of Saudi ArabiaUKRI Engineering and Physical Sciences Research Council EP/S028323/1
6 · The paper itself

Abstract

Peptide-based vaccines, formulated with an appropriate adjuvant, offer a versatile platform for targeted cancer immunotherapy. While adjuvants are usually coadministered for nucleic acid and protein vaccines, synthetic peptide antigens afford a more effective opportunity to covalently and regioselectively graft immunostimulatory motifs directly onto the antigen scaffold to yield self-adjuvanting vaccines. Herein, we explore the synthesis of two tissue-restricted cancer-testis antigens (CTAs); New York oesophageal cell carcinoma 1 (NY-ESO-1) and B melanoma antigen 4 (BAGE4), both carrying the toll-like receptor (TLR) agonist, Pam

Indexed as

Adjuvants, ImmunologicAntigens, NeoplasmCancer VaccinesMembrane ProteinsAnimalsHumansMaleMiceNanoparticlesTestisAdjuvants, ImmunologicAntigens, NeoplasmCancer VaccinesCTAG1B protein, humanMembrane Proteinsadjuvantcancer‐testis antigenpeptidevaccine

Identifiers

PMID40326329
PMCPMC12053792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.