Evidence map›Paper›PMID 40326273›Full record

ArticleThe Laryngoscope2025

Transcriptomic Features of Recurrence Rates in Idiopathic Subglottic Stenosis.

Shengjie Ying, Peter Y F Zeng, Kevin Fung, Halema Khan, Matthew J Cecchini, Elissa Woo, Jennifer Anderson, Patrick MacInnis, Amir H Karimi, MohdWessam Al Jawhri and 11 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07654517 (A Phase I Evaluation of the Safety and Tolerability of Pirfenidone in Idiopathic Subglottic Stenosis), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07654517 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Phase I Evaluation of the Safety and Tolerability of Pirfenidone in Idiopathic Subglottic Stenosis

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2026 to 2029Enrolled40ConditionsIdiopathic Subglottic Stenosis, Subglottic Stenosis (SGS)ArmsPirfenidone 267 MG [Esbriet], Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Shengjie YingDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.ORCID https://orcid.org/0009-0008-3094-3129
Peter Y F ZengDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Kevin FungDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Halema KhanDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Matthew J CecchiniDepartment of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Elissa WooDepartment of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Jennifer AndersonDepartment of Otolaryngology-Head and Neck Surgery, Temerty Faculty of Medicine, Unity Health Toronto, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-7080-9567
Patrick MacInnisDepartment of Otolaryngology-Head and Neck Surgery, Temerty Faculty of Medicine, Unity Health Toronto, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Amir H KarimiDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
MohdWessam Al JawhriDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Harrison PanDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Nhi LeDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Krista JorisDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Rui WenDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Joe S MymrykDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Richard InculetDivision of Thoracic Surgery, Western University, London, Ontario, Canada.
Vanessa DumeauxDepartment of Oncology, Western University, London, Ontario, Canada.
John W BarrettDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Anthony C NicholsDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
R Jun LinDepartment of Otolaryngology-Head and Neck Surgery, Temerty Faculty of Medicine, Unity Health Toronto, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-1064-5868
Canadian Airways Research Group of the Canadian Society of Otolaryngology Collaborative Research Initiative

Funding

Academic Medical Organization of Southwestern Ontario INN21-016American Laryngological Association ALVRE Grant #1082Canadian Institute of Heath Research Canada Graduate Scholarship-DoctoralWolfe Surgical Research Professorship in the Biology of Head and Neck Cancers
6 · The paper itself

Abstract

objectiveIdiopathic subglottic stenosis (iSGS) is a rare disease characterized by narrowing of the upper airway and affects near-exclusively females. Patients often experience recurrent disease and require repeated surgical dilations. The pathophysiology underlying the broad spectrum of disease severity within iSGS remains unknown. In the current study, we sought to identify transcriptomic differences between iSGS patients with markedly different recurrence rates.

methodsProspectively collected clinical and bulk RNA sequencing data from subglottic tissues of 56 female iSGS patients with 1-4 years of follow-up were analyzed. DESeq2 was used to perform differential expression analysis, comparing samples from the highest (1.19-1.87 dilations/year) versus the lowest (0.30-0.65 dilations/year) quartile of surgical dilation rate (i.e., high vs. low recurrence groups).

resultsIn total, 220 genes were significantly differentially expressed between the high and low recurrence groups (adjusted p < 0.1 and log

conclusionTranscriptomic profiling suggests that lower recurrence rates in iSGS are associated with retention of respiratory cilia, while adaptive immune responses and increased extracellular matrix deposition are present in those with higher recurrence rates. These results hold promise for the development of prognostic markers and identification of therapeutic targets for iSGS.

Indexed as

LaryngostenosisTranscriptomeAdultAgedFemaleFollow-Up StudiesGene Expression ProfilingHumansMiddle AgedProspective StudiesRecurrenceadaptive immunityB cellextracellular matrixfibrosisidiopathic subglottic stenosis (iSGS)RNA sequencingsurgical endoscopic dilation

Identifiers

PMID40326273
PMCPMC12371795

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.