Evidence map›Paper›PMID 40326261›Full record

ArticleThe Laryngoscope2025

Unilateral Sensorineural Hearing Loss in Children: Natural History and Clinical Characteristics.

Olivia Kalmanson, Jennifer Drohosky, Laura Greaver, Nathan Cass, Renee Banakis-Hartl, Maksym Goryachok, Sean R Anderson, Kenny H Chan

Abstract read
In one paragraph

Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olivia KalmansonDepartment of Otolaryngology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-0130-0684
Jennifer DrohoskyDepartment of Audiology, Children's Hospital Colorado, Aurora, Colorado, USA.
Laura GreaverDepartment of Audiology, Children's Hospital Colorado, Aurora, Colorado, USA.
Nathan CassDepartment of Otolaryngology, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0003-2654-2812
Renee Banakis-HartlDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6254-1908
Maksym GoryachokUniversity of Colorado School of Medicine, Aurora, Colorado, USA.
Sean R AndersonDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-1638-0197
Kenny H ChanDepartment of Otolaryngology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0001-9989-1322

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Institutional Training in Otolaryngology ResearchT32DC012280 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Yuri Agrawal, Sue C. Kinnamon · 2013 to 2026
$3.4M
NCATS NIH HHS UL1 TR002535NIDCD NIH HHS T32 DC012280
6 · The paper itself

Abstract

objectiveCharacterize hearing outcomes and etiologies of congenital and postnatal unilateral sensorineural hearing loss (SNHL).

methodsReviewed charts of children with unilateral SNHL, 2003-2019. Primary outcomes were changes in pure tone average (PTA) of affected and contralateral ears. Patients who failed a newborn hearing screen (NBHS) were considered 'congenital' onset, those who passed "postnatal," and those without "unknown." Demographics, infectious/genetic workup, audiograms, imaging, and hearing aid use were collected.

resultsA total of 1264 charts reviewed, 476 subjects included: 156 congenital, 252 postnatal, and 68 unknown onset. The mean (SD) of the first PTA was 53.8(29.4) dB for affected and 10.6(5.8) dB for unaffected ears. Thirty-nine percent followed up > 5 years. Change in PTA over time was 3.0(14.5) dB for affected and -1.7(7.4) dB for unaffected ears. The congenital subgroup had poorer hearing in the affected ear at the first audiogram (p < 0.0001) and was more likely to have progressive hearing loss (p = 0.0040) than the postnatal subgroup. Imaging in 296 patients revealed ipsilateral abnormalities in 26.6% of CTs and 39.6% of MRIs. Absent/hypoplastic cochlear nerve was the most common abnormal and was associated with poorer hearing than those with normal nerves (p < 0.0001). Enlarged vestibular aqueduct was not associated with progression of hearing loss.

conclusionHearing in both the affected and contralateral ears remained stable after the first audiogram in > 80% of patients. Patients with congenital loss had poorer hearing at diagnosis and were more likely to have progression than those with postnatal loss. MRI was more sensitive than CT in detecting an anatomic cause of SNHL, and absent/hypoplastic cochlear nerve was the most common finding. LEVEL OF EVIDENCE: 4:

Indexed as

Hearing Loss, SensorineuralHearing Loss, UnilateralAudiometry, Pure-ToneChildChild, PreschoolDisease ProgressionFemaleHearing AidsHumansInfantInfant, NewbornMaleNeonatal ScreeningRetrospective Studiescongenital anomaliespediatric hearing losssensorineural hearing loss

Identifiers

PMID40326261
PMCPMC12353412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.