Observational studyBasic & clinical pharmacology & toxicology2025
Poisonings With Opioids and Benzodiazepines in Denmark: A Retrospective Study From the Danish Poison Information Centre.
Observational study in Basic & clinical pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Drug-induced polycystic ovary syndrome: a real-world pharmacovigilance study based on the FAERS database.Frontiers in endocrinology · 2025Article
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3 authors.
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Abstract
introductionThis study describes opioid and benzodiazepine poisonings in Denmark from 2014 to 2022. The analgesic effect of opioids and sedative effect of benzodiazepines are used to treat pain, insomnia and anxiety disorders and can cause abuse and addiction. MATERIALS AND
methodsA retrospective observational register study with data from the Danish Poison Information Centre with alprazolam, clonazepam, oxazepam, buprenorphine, diacetylmorphine, methadone, morphine, oxycodone and tramadol poisonings. Multiple recordings of the same exposure are only registered once.
resultsTotally 10 965 enquiries were included with a 55/43% female/male ratio (2% unaccounted). The number of enquiries regarding poisonings with alprazolam increased from 56 in 2014 to 289 in 2022 (+416%) or from 2.27 to 7.71 per 1000 enquiries to the DPIC (+240%). The corresponding numbers regarding the other eight substances were buprenorphine [22/33 (+50%); 0.89/0.88 (-1%)], morphine [125/250 (+100%); 5.06/6.67 (+32%)], oxazepam [240/364 (+52%); 9.71/9.71 (0%)], oxycodone [44/199 (+352%); 1.78/5.31 (+198%)], tramadol [262/421 (+61%); 10.6/11.23 (+6%)], methadone [65/63 (-3%); 2.63/1.68 (-36%)], clonazepam [60/92 (+53%); 2.43/2.45 (+1%)] and diacetylmorphine [17/20 (+18%); 0.69/0.53 (-23%)].
conclusionIn our 9-year study period, we observed large increases in poisonings with alprazolam and oxycodone. In the remaining drugs examined, we observed no change or even a reduction of the poisonings when adjusted for the general increase in enquiries to the DPIC.
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