ArticleCNS neuroscience & therapeutics2025
Regulation of Nrf2/GPX4 Signaling Pathway by Hyperbaric Oxygen Protects Against Depressive Behavior and Cognitive Impairment in a Spinal Cord Injury Rat Model.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Electroacupuncture ameliorates cognitive impairment after spinal cord injury via BDNF/TrkB/CREB-mediated hippocampal neurorestoration.IBRO neuroscience reports · 2026Article
- Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.Biochemistry and biophysics reports · 2026Review
- PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spinal cord injury induces mitochondrial dysfunction and metabolic reprogramming in non-regenerativeiScience · 2026Article
- Hyperbaric Oxygen Attenuates Cerebral Ischemia-Reperfusion Injury Through ROS-Dependent Remodeling of Microglial Mitochondrial Dynamics.International journal of molecular sciences · 2026Article
- Selenoproteins: Minute yet vital players governing cellular fate.Genes & diseases · 2026Review
- Anti-HMGB1 Antibody Therapy Ameliorates Depression Following Spinal Cord Injury in Rats by Inhibiting Ferroptosis.Journal of cellular and molecular medicine · 2026Article
- Inflachromene Blocks Neuronal HMGB1 Translocation to Mitigate Hippocampal TLR4-NF-κB-Mediated Neuroinflammation and Depression-Like Behavior After Spinal Cord Injury.Molecular neurobiology · 2026Article
- CB2R-mediated GPX4 stabilization: a new avenue for treating cognitive impairment in elderly migraine patients.The journal of headache and pain · 2026Article
- Interplay between the gut microbiota and MAPK/NF-κ B/Nrf2 signaling in depression: pharmacological insights from traditional Chinese medicine.Frontiers in pharmacology · 2026Review
- Hyperbaric oxygen therapy in sepsis-associated encephalopathy: pathophysiological rationale, preclinical evidence, and translational challenges.Frontiers in cellular neuroscience · 2026Review
- Hyperbaric oxygen treatment and toll-like receptor 5 in radioprotection of epithelial cells.PloS one · 2026Article
- Neuroprotective Mechanisms of Hyperbaric Oxygen Therapy in Cerebral Ischemia-Hypoxia Injury Following Cardiopulmonary Resuscitation.International journal of medical sciences · 2026Review
- Targeting ferroptosis with culinary spices: a dietary strategy for neuroprotection via the Nrf2/GPX4 axis.Frontiers in nutrition · 2026Review
- Potential Mechanisms of Exercise-Mediated Ferroptosis Regulation in Central Nervous System Diseases.Molecular neurobiology · 2025Review
- Effects of combined atorvastatin calcium and hyperbaric oxygen therapy on postoperative recovery in patients with traumatic brain injury.American journal of translational research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
aimsNeuroinflammation, microglial activation, and oxidative stress contribute to neuropsychiatric deficits following spinal cord injury (SCI). Hyperbaric oxygen (HBO) therapy has demonstrated anti-inflammatory, antioxidant, and neuroprotective properties. This study aimed to investigate the therapeutic effects and underlying mechanisms of HBO on depressive-like behavior, cognitive impairment, and hippocampal pathology in a rat model of SCI.
methodsWe employed a battery of behavioral assessments, unbiased stereological analysis, immunofluorescence staining, and biochemical assays to evaluate neuroinflammation, oxidative stress, mitochondrial damage, and iron accumulation in the hippocampus. Untargeted proteomic analysis was conducted to identify potential molecular targets of HBO. Western blotting was used to assess the activation of the Nrf2/GPX4 signaling pathway. ML385, a selective Nrf2 inhibitor, was intrathecally administered 30 min prior to daily HBO treatment to validate pathway involvement.
resultsHBO treatment significantly alleviated depressive-like behavior and cognitive deficits in SCI rats. It also suppressed M1-type microglial activation and reduced hippocampal neuroinflammation. Additionally, HBO mitigated neuronal ferroptosis induced by SCI through activation of the Nrf2/GPX4 signaling pathway. The protective effects of HBO were abolished by coadministration of ML385, confirming the critical role of Nrf2 signaling in mediating its anti-ferroptosis effects.
conclusionThese findings highlight ferroptosis as a key pathological mechanism in SCI-induced hippocampal damage and suggest that HBO therapy alleviates depressive-like behavior and cognitive impairment by targeting the Nrf2/GPX4 pathway. This study provides new insights into the therapeutic potential of HBO in managing SCI-related neuropsychiatric dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.