ArticleCombinatorial chemistry & high throughput screening2026
Circulating Inflammatory Proteins and Age-related Macular Degeneration: New Insights from Mendelian Randomization.
Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Integrating plasma proteomics and genome-wide association data to identify therapeutic targets for retinal neurodegenerative diseases in Europeans.International journal of ophthalmology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInflammation is a critical mechanism in the development of age-related macular degeneration (AMD); however, the specific circulating inflammatory proteins involved remain unclear. This study aimed to assess the causal relationships between 91 circulating inflammatory proteins and AMD using a two-sample Mendelian randomization (MR) approach.
methodsWe performed two-sample MR analyses using genome-wide association study (GWAS) summary statistics. Five MR methods were applied, with inverse variance weighting (IVW) as the primary approach. False discovery rate (FDR) correction was used to adjust for multiple testing. Sensitivity analyses assessed heterogeneity and horizontal pleiotropy. Steiger's test, reverse MR, and linkage disequilibrium score regression (LDSC) were used for validation.
resultsHigher levels of CCL11, SLAMF1, and VEGF-A, and lower levels of FGF-19 and IL-10RA, were significantly associated with increased AMD risk. Higher IL-15RA and VEGF-A, and lower IL- 10RA, were associated with wet AMD, while lower FGF-19 was associated with dry AMD. LDSC analyses indicated that, except for FGF-19, no genetic correlation confounded these associations. Reverse MR showed no evidence that AMD liability influenced the expression of the identified proteins. DISCUSSION: Our findings, via MR analysis, indicate a potential causal relationship between circulating inflammatory proteins and AMD. This sheds new light on AMD pathophysiology and suggests possible therapeutic targets. Further research is required to confirm these results and understand the specific roles of these proteins in AMD.
conclusionThis study supports causal links between specific inflammatory proteins and AMD. Incorporating inflammation modulation into personalized treatment strategies may enhance AMD management.
Indexed as
Identifiers
40326035What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.