Evidence map›Paper›PMID 40325986›Full record

Trial reportEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2025

Prognostic implications and predictive factors of subclinical leaflet thrombosis following valve-in-valve transcatheter aortic valve implantation.

Takashi Nagasaka, Vivek Patel, Kazuki Suruga, Yuchao Guo, Ofir Koren, Alon Shechter, Michelle Friedman, Dhairya Patel, Tarun Chakravarty, Wen Cheng and 5 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02318342 (Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic Valve Dysfunction With Multimodality Imaging and Its TrEatment With Anticoagulation), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02318342 narecruitingnot on this map

Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic Valve Dysfunction With Multimodality Imaging and Its TrEatment With Anticoagulation

TypeinterventionalSponsorCedars-Sinai Medical CenterRan2014 to 2028Enrolled3,000ConditionsProsthetic Valve ThrombosisArmsWarfarin
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Further insights on subclinical leaflet thrombosis following valve-in-valve TAVI.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Takashi NagasakaCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Vivek PatelCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Kazuki SurugaCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Yuchao GuoCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Ofir KorenCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Alon ShechterCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Michelle FriedmanCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Dhairya PatelCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Tarun ChakravartyCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Wen ChengCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Aakriti GuptaCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Hideki IshiiDepartment of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Gunma, Japan.
Hasan JilaihawiCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Mamoo NakamuraCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Raj R MakkarCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubclinical leaflet thrombosis, as indicated by hypoattenuated leaflet thickening (HALT) on computed tomography (CT) imaging, remains a major concern owing to its potential impact on valve function and patient outcomes.

aimsWe aimed to evaluate the association between HALT and clinical outcomes in patients undergoing valve-in-valve (ViV) transcatheter aortic valve implantation (TAVI) with balloon-expandable valves and to identify predictors of leaflet thrombosis.

methodsConsecutive patients who underwent ViV TAVI with balloon-expandable valves at the Cedars-Sinai Medical Center were retrospectively analysed. We analysed both pre- and postprocedural CT scans to identify predictors of HALT at 1 month after ViV TAVI and the association of HALT with clinical outcomes. The primary outcome was a composite of all-cause mortality, hospitalisation for heart failure (HF), or stroke at 3 years.

resultsAmong the 117 patients analysed, HALT was detected in 37 (31.6%). In the multivariable analysis, anticoagulation therapy (odds ratio [OR] 0.28, 95% confidence interval [CI]: 0.08-0.92; p=0.037) and greater transcatheter heart valve (THV) expansion at the minimum area level (OR 0.95, 95% CI: 0.91-0.99; p=0.026) were significant predictors of reduced HALT following ViV TAVI. While there was no significant difference in all-cause mortality between patients with and without HALT (OR 1.13, 95% CI: 0.42-3.02; p=0.8), those with HALT had a significantly higher incidence of the composite primary outcome (OR 2.31, 95% CI: 1.04-5.15; p=0.04).

conclusionsHALT was frequently observed in patients who underwent ViV TAVI. Additionally, the presence of HALT correlated with a higher incidence of composite outcomes, including all-cause mortality, hospitalisation for HF, and stroke. Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic VaLVe Dysfunction and Its TrEatment with Anticoagulation (RESOLVE; ClinicalTrials.gov: NCT02318342).

Indexed as

Aortic ValveAortic Valve StenosisHeart Valve ProsthesisThrombosisTranscatheter Aortic Valve ReplacementAgedAged, 80 and overAnticoagulantsFemaleHumansMalePrognosisProspective StudiesRetrospective StudiesRisk FactorsTomography, X-Ray ComputedAnticoagulants

Identifiers

PMID40325986
PMCPMC12038364

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.