ArticleAnimal models and experimental medicine2025
Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats.
Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats.Animal models and experimental medicine · 2025Article
- Evaluation of Citral and Green Silver Nanoparticles FromBioMed research international · 2025Article
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7 authors.
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Abstract
backgroundDiabetes, a metabolic disease marked by endocrine dysfunctions, significantly impacts oxidative stress pathways. This study explores the protective effects of lemongrass extract (LE), citral, and lemongrass extract-synthesized silver nanoparticles (LE-AgNP) against hyperglycemia-induced oxidative stress by modulating the Nrf2 pathway, which is crucial for antioxidant responses.
methodsVarious techniques characterized the nanoparticles, including ultraviolet-visible spectroscopy, dynamic light scattering, zeta potential analysis, Fourier-transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. Seventy rats, divided into seven groups, were used for in vivo experiments. Type 2 diabetes was induced using streptozotocin (65 mg/kg) and nicotinamide (90 mg/kg). After six weeks, biochemical parameters such as total antioxidant capacity, malondialdehyde, Nrf2, and Nrf2 miRNA were evaluated in pancreas tissue and blood serum, along with serum blood glucose levels.
resultsLE-AgNP significantly improved weight gain, reduced food and water intake, and lowered blood glucose levels in diabetic rats. LE and citral did not significantly alter these parameters but prevented the decline in Nrf2 gene expression. LE-AgNP showed a significant increase in Nrf2 gene expression compared to the diabetic control group.
conclusionsThis study highlights the potential of LE, citral, and especially LE-AgNP in mitigating oxidative stress induced by diabetes. LE-AgNP demonstrated superior therapeutic benefits, including improved oxidative stress conditions and hypoglycemic effects.
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