Evidence map›Paper›PMID 40325944›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025

The Importance of Extranodal Extension Grading in Laryngeal Squamous Cell Carcinoma.

Hakan Kara, Levent Aydemir, Melek Büyük, Erol Bozbora, Kübra Özkaya Toraman, Saim Pamuk, Kağan Avcı, Comert Sen, Said Sonmez, Murat Ulusan and 3 more

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Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hakan KaraDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-3079-6866
Levent AydemirDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Melek BüyükDepartment of Pathology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Erol BozboraDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Kübra Özkaya ToramanDepartment of Radiation Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
Saim PamukDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Kağan AvcıDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Comert SenDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Said SonmezDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Murat UlusanDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Bora BasaranDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Musa AltunDepartment of Radiation Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
Erkan KıyakDepartment of Otorhinolaryngology-Head and Neck Surgery, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe primary objective was to investigate the effect of extra-nodal extension (ENE) grading on the survival of pN-positive patients with laryngeal squamous cell carcinoma (LSCC). STUDY

designA retrospective cohort study.

settingA tertiary referral center.

methodsThe patients with LSCC were retrospectively reviewed. The histopathological slides of patients were re-examined, and ENE was graded. Survival analyses were performed.

resultsSeventy-six patients were enrolled in this study. The average age of patients was 61.29 years. 3-year overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) rates were 69.7%, 73.7%, and 73.7%, respectively. ENE grading had no statistically significant impact on survival rates.

conclusionWhile the presence of ENE in more than 4 lymph nodes, lymph node density (LND) greater than 0.2, poor histologic differentiation, and not receiving chemotherapy were identified as independent poor prognosticators in LSCC, the study did not show any effect of ENE grading on survival rates.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsAdultAgedAged, 80 and overDisease-Free SurvivalExtranodal ExtensionFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm GradingNeoplasm StagingPrognosisRetrospective Studiescancerextra‐nodal extensionlarynxlymph node density

Identifiers

PMID40325944
PMCPMC12379844

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.