Evidence map›Paper›PMID 40325908›Full record

ArticleACS applied materials & interfaces2025

Transition Temperature-Guided Design of Lipid Nanoparticles for Effective mRNA Delivery.

Jeong Eun Shin, Eun-Jeong Won, Junchao Xu, Jong Cheol Lee, Jeong Kyu Bang, Michael J Mitchell, Hyunjoo Cha-Molstad

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeong Eun ShinNucleic Acid Therapeutics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang 28116, Republic of Korea.ORCID 0000-0002-5986-7069
Eun-Jeong WonNucleic Acid Therapeutics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang 28116, Republic of Korea.ORCID 0000-0003-4517-3434
Junchao XuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-0725-8111
Jong Cheol LeeDandicure Inc, Ochang, Chung Buk 28119, Republic of Korea.ORCID 0009-0002-5779-0763
Jeong Kyu BangDivision of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang 28116, Republic of Korea.ORCID 0000-0001-5916-0912
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-3628-2244
Hyunjoo Cha-MolstadNucleic Acid Therapeutics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang 28116, Republic of Korea.ORCID 0000-0003-3676-7150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid nanoparticles (LNPs) are promising mRNA delivery vehicles due to their biocompatibility and tunable characteristics. While current rational design approaches focus on ionizable lipids' p

Indexed as

LipidsNanoparticlesRNA, MessengerAnimalsHumansLiposomesMicePhosphatidylethanolaminesTransfectionTransition TemperatureLipid NanoparticlesLipidsLiposomesPhosphatidylethanolaminesRNA, Messengerionizable lipidlipid nanoparticlemRNAnDSCSAXS

Identifiers

PMID40325908
PMCPMC12086761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.