Evidence map›Paper›PMID 40325896›Full record

ArticleMicrobial biotechnology2025

Fimsbactin Siderophores From a South African Marine Sponge Symbiont, Marinomonas sp. PE14-40.

Nompumelelo Philile Praiseworth Ikegwuoha, Thea Hanekom, Elzaan Booysen, Corbyn Jason, Shirley Parker-Nance, Michael T Davies-Coleman, Leonardo Joaquim van Zyl, Marla Trindade

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Article in Microbial biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nompumelelo Philile Praiseworth IkegwuohaDepartment of Biotechnology, Institute for Microbial Biotechnology and Metagenomics (IMBM), University of the Western Cape, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-2153-850X
Thea HanekomDepartment of Biotechnology, Institute for Microbial Biotechnology and Metagenomics (IMBM), University of the Western Cape, Cape Town, South Africa.
Elzaan BooysenDepartment of Biotechnology, Institute for Microbial Biotechnology and Metagenomics (IMBM), University of the Western Cape, Cape Town, South Africa.
Corbyn JasonDepartment of Biotechnology, Institute for Microbial Biotechnology and Metagenomics (IMBM), University of the Western Cape, Cape Town, South Africa.
Shirley Parker-NanceDepartment of Zoology, Nelson Mandela Metropolitan University, University Way, Port Elizabeth, South Africa.
Michael T Davies-ColemanDepartment of Chemistry, University of the Western Cape, Cape Town, South Africa.
Leonardo Joaquim van ZylDepartment of Biotechnology, Institute for Microbial Biotechnology and Metagenomics (IMBM), University of the Western Cape, Cape Town, South Africa.
Marla TrindadeDepartment of Biotechnology, Institute for Microbial Biotechnology and Metagenomics (IMBM), University of the Western Cape, Cape Town, South Africa.

Funding

DSI/NRF SARChI research chair in Microbial Genomics 87326European Union PharmaSea Consortium 312184National Research Foundation 129660South African Medical Research Council (Self-Initiated grant)
6 · The paper itself

Abstract

Low iron levels in marine habitats necessitate the production of structurally diverse siderophores by many marine bacterial species for iron acquisition. Siderophores exhibit bioactivities ranging from chelation for iron reduction in hemochromatosis sufferers to antimicrobial activity either in their own right or when coupled to known antibiotics for targeted delivery or for molecular imaging. Thus, marine environments are a sought-after resource for novel siderophores that could have pharmaceutical or industrial application. The fimsbactins A-F (1-6) are mixed catechol-hydroxamate siderophores that have only been reported to be produced by Acinetobacter species with the fimsbactin biosynthetic gene clusters (BGCs) widespread among species within this genus. Here, we identified a putative fimsbactin BGC from an uncharacterized marine isolate, Marinomonas sp. PE14-40. Not only was the gene synteny not conserved when comparing the pathway from Marinomonas sp. PE14-40 to the fimsbactin BGC from Acinetobacter sp., but five of the core biosynthetic genes found in the canonical fimsbactin BGC are located elsewhere on the genome and do not form part of the core cluster in Marinomonas sp. PE14-40, with four of these, fbsBCDL, colocalized. Through ESI-MS/MS analysis of extracts from Marinomonas sp. PE14-40, the known fimsbactin analogues 1 and 6 were identified, as well as two new fimsbactin analogues, 7 and 8, containing a previously unreported L-lysine-derived hydroxamate moiety, N

Indexed as

PoriferaSiderophoresAnimalsBiosynthetic PathwaysHydroxamic AcidsMultigene FamilySymbiosisHydroxamic AcidsSiderophoresbiosynthetic gene cluster (BGC)fimsbactinhydroxamateLC–MSmarine bacteriaN1‐acetyl‐N1‐hydroxy‐cadaverinesiderophore

Identifiers

PMID40325896
PMCPMC12053065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.