ArticleThe New phytologist2025
Protection of naringenin chalcone by a pathogenesis-related 10 protein promotes flavonoid biosynthesis in Marchantia polymorpha.
Article in The New phytologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Tuning reductase activity in monoterpene indole alkaloid biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Biosynthesis and Functions of Flavonoids: Recent Advances From Studies Across Land Plant Diversity.Journal of the Royal Society of New Zealand · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Pathogenesis-related (PR) proteins are diverse stress- or pathogen-induced proteins. Some are associated with specialised metabolism, including proposed functions for anthocyanin biosynthesis. However, data are limited to a few angiosperm species, and the mode(s) of action are uncertain. Using the liverwort Marchantia polymorpha (Marchantia), we examined whether pathogenesis-related 10 (PR10) contributes to flavonoid biosynthesis in other land plant lineages and investigated its mode of action. Marchantia produces two major flavonoid types: flavones and the pigment auronidin. MpPR10.5 is a target of the auronidin regulator MpMYB14; therefore, Mppr10.5 mutants were generated using CRISPR/Cas9 and analysed for transcript abundance (via RNA sequencing) and for metabolite content. Recombinant MpPR10.5 protein was used for metabolite binding and stabilisation assays. Mppr10.5 mutants had reduced auronidin and flavone content, demonstrating that MpPR10.5 promotes flavonoid biosynthesis. Flavone and auronidin biosynthesis share a single flavonoid intermediate, naringenin chalcone (NC), suggesting MpPR10.5 acts on this compound. MpPR10.5 protein binds NC strongly (micromolar affinity), preventing spontaneous self-cyclisation in vitro. Several phenylpropanoid and flavonoid genes were downregulated in Mppr10.5 and Mpchalcone isomerase-like plants. This suggests PR10 proteins promote flavonoid biosynthesis by selectively binding unstable intermediates (NC), protecting them from degradation or undesirable nonenzymatic conversions and facilitating their transport to subsequent pathway steps.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.