ArticleJournal of the American Chemical Society2025
From Reagent to Catalyst: Dispersion-Driven Design of a General Asymmetric Transfer Hydrogenation Catalyst.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- London Dispersion in Confined Chiral Ion-Pair Asymmetric Catalysis: From Background Interaction to Design Principle.Accounts of chemical research · 2026Article
- London Dispersion Governs Stereochemistry, Stability, and Self-Sorting in a System of MJournal of the American Chemical Society · 2026Article
- Article
- Stereoselective Generalizations over Diverse Sets of Chiral Acids Enabled by Buried Volume.Journal of the American Chemical Society · 2026Article
- Catalytic Asymmetric Ionic Hydrogenation of α-Alkyl Styrenes.Journal of the American Chemical Society · 2025Article
- London Dispersion as a Design Element in Molecular Catalysis.Journal of the American Chemical Society · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though chemists have long underappreciated the role of London dispersion in catalysis, its importance in determining a reaction course is now well recognized. Dispersion interactions have been shown to stabilize transition states and govern the stereoselectivity. In this context, the transfer hydrogenation of α,β-unsaturated aldehydes reported by our group via asymmetric counteranion-directed catalysis (ACDC) was revisited mechanistically. Previously, the use of an engineered Hantzsch ester featuring an isopropyl group was crucial for high enantioselectivity, suggesting London dispersion as an important stereocontrolling factor. Based on this hypothesis and the method's drawbacks (commercially unavailable Hantzsch ester, limited substrate scope, high catalyst loadings), we designed a broadly applicable second-generation catalyst system by introducing dispersion energy donors into the catalyst instead of the Hantzsch ester reagent. With the help of computational analysis, noncovalent interactions contributing to stereocontrol in the two systems were elucidated.
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Registered trials
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