ArticleRenal failure2025
Global glomerulosclerosis proportions predict nephropathy progression in IgA nephropathy: a multicenter retrospective analysis with propensity score matching.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Finerenone in IgA nephropathy: real-world 12-month propensity-matched cohort demonstrating proteinuria reduction, eGFR preservation, and safety profile.Renal failure · 2026Article
- Histopathological predictors of renal outcomes in idiopathic membranous nephropathy with a focus on global sclerotic glomeruli ratio.Scientific reports · 2026Article
- Serum sclerostin in biopsy-proven glomerulonephritis primarily reflects kidney function: a cross-sectional case-control study.International urology and nephrology · 2026Article
- Prognostic value of the ratio of globally sclerotic glomeruli in patients with idiopathic IgA nephropathy.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide. The role of global glomerulosclerosis (GS) in the patients with IgAN remains controversial. The study aims to evaluate the effect of GS on the kidney outcome in the patients with IgAN.
methodsBased on the median of GS proportion, patients were divided into two groups (GS1 and GS2). Thereafter, the clinical, demographic, and treatment characteristics were evaluated by propensity score matching, Kaplan-Meier survival curves, Cox regression analyses. Next, the receiver operating characteristic curve analysis, continuous net reclassification improvement and integrated discrimination improvement were constructed to assess whether the model contained GS proportion could refine risk prediction and clinical utility.
resultsIn this three-center retrospective study, a total of 1,626 IgAN patients were recruited. Both in the full and matched cohort, higher GS proportions were found to be independent prognostic factors for the kidney survival
conclusionsGS proportions are independent predictors for poor prognosis in IgAN patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.