Evidence map›Paper›PMID 40325543›Full record

ArticleCurrent medicinal chemistry2025

Azole Homodimers as Promising Antifungal Agents: Synthesis, Biological Activity Evaluation and Molecular Modeling.

Sergey N Lavrenov, Alexander Yu Simonov, Alexey A Panov, Svetlana E Solovieva, Alexey B Mantsyzov, Andrei V Churakov, Alexey S Trenin, Igor B Levshin

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Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sergey N LavrenovGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.ORCID 0000-0001-8521-0960
Alexander Yu SimonovGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.ORCID 0000-0002-5036-2179
Alexey A PanovGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.ORCID 0000-0002-6654-4081
Svetlana E SolovievaGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.ORCID 0000-0002-5803-0523
Alexey B MantsyzovFaculty of Fundamental Medicine, Lomonosov Moscow State University, 27/1 Lomonosovsky Ave., Moscow, 119991, Russia.
Andrei V ChurakovKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Ave., 117901, Moscow, Russia.
Alexey S TreninGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.
Igor B LevshinGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.ORCID 0000-0003-1024-9099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA new series of triazoles with antifungal activity have been synthesized in a one-step fashion by direct reaction of 2-(2,4-difluorophenyl)-2,3-epoxy- 1-(1H-1,2,4-triazol-1-yl)propane with various diamines.

methodsObtained compounds were profiled for biological activity against pathogenic strains of fungi

resultsThe lead compound was 4 times more active against C. albicans than fluconazole and demonstrated a wider spectrum of activity, inhibiting the growth of A. niger.

conclusionThe results presented herein can contribute to the development of novel antifungal therapeutic agents.

Indexed as

Antifungal AgentsAspergillus nigerAzolesCandida albicansDimerizationMicrobial Sensitivity TestsModels, MolecularMolecular StructureStructure-Activity RelationshipAntifungal AgentsAzolesAntifungalsazolesdiamineshomodimersitraconazole.ketoconazole

Identifiers

PMID40325543

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