Evidence map›Paper›PMID 40325483›Full record

ReviewEuropean journal of medical research2025

The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review.

Zhu Zhang, Xin Wang

Abstract readReview
In one paragraph

Review in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhu ZhangThe First Clinical Institute, Zunyi Medical University, Zunyi City, 563000, Guizhou Province, China.
Xin WangThe First Clinical Institute, Zunyi Medical University, Zunyi City, 563000, Guizhou Province, China. 110667637@qq.com.

Funding

Natural Science Foundation of Guizhou Province GZSYQCC 【2023】006
6 · The paper itself

Abstract

This scoping review aims to synthesize evidence regarding the neural mechanisms and pathways underlying postoperative nausea and vomiting (PONV). We systematically searched the PubMed, Embase and Cochrane Library databases up to 2024. The findings indicate that PONV is a common complications after surgeries involving anaesthesia and can also lead to severe postoperative discomfort. Various surgical procedures and anaesthesia methods can trigger PONV, and the underlying neural mechanisms and signalling pathways are complex. It is currently assumed that these pathways do not exist independently of each other but that a central mode generator encompasses all relevant neurons and conducting nerve fibres, including the nucleus of the solitary tract, the dorsal nucleus of the tenth nerve, the area of the nerve, etc. After the information is integrated, it is transferred to the digestive tract, thereby causing PONV. In this article, we discuss the progress of research on the factors that influence PONV and identify the underlying pathways.

Indexed as

Neural PathwaysPostoperative Nausea and VomitingHumansSignal TransductionAnaesthesiaInducementNeural pathwaysPostoperative nausea and vomiting

Identifiers

PMID40325483
PMCPMC12054289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.